バルニジピン

バルニジピン 化学特性,用途語,生産方法

• 効能

  血圧降下薬, カルシウムチャネル遮断薬

• 説明

  Barnidipine is a long-acting novel calcium antagonist that belongs to the dihydropyridine (DHP) group of calcium channel blockers. It contains two chiral centres thus can have four possible enantiomers. The active component is composed of a single optical isomer (3'S, 4S configuration), which is the most potent and longest-acting of the four enantiomers. Barnidipine has shown to be an effective antihypertensive agent in the management of hypertension in elderly patients and its efficacy is not negatively affected by age.

• Originator

  Barnidipine,Yamanouchi

• Manufacturing Process

  In 5 ml of isopropyl alcohol were dissolved 1.5 g (0.01 mole) of 3- nitrobenzaldehyde, 2.6 g (0.01 mole) of 1-benzyl-3-acetoacetyloxypyrrolidine, and 1.3 g (0.01 mole) of β-aminocrotonic acid methyl ester and then the solution was refluxed for 8 hours. The solvent was distilled off under reduced pressure, the residue obtained was dissolved in a small amount of chloroform, and the solution was applied to silica gel column chromatography (column diameter 1.5 cm, height 20 cm, and about 200 ml of chloroform was used as the eluent). The eluates were collected and concentrated to give 3.4 g of oily 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3- (1-benzylpyrrolidin-3-yl)ester-5-methyl ester: [α]D 20=+64.8° (c = 1 in methanol).

• Therapeutic Function

  Coronary vasodilator

• 副作用

  The side effects of barnidipine are typically mild to moderate and typically occur at the beginning of treatment. Common side effects include nausea, palpitations, flushed face, hot flashes, swelling, headache, heavy sensation in the head, dizziness, and a feeling of unsteadiness. Other reported side effects include redness, rash, itching, and sensitivity to sunlight.

• 参考文献

  [1] LIAUCHIAU-SUONG. Barnidipine: a new calcium channel blocker for hypertension treatment.[J]. Expert Review of Cardiovascular Therapy, 2005. DOI:10.1586/14779072.3.2.207.
  [2] CHENGZHI-GANG. Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance.[J]. Molecules, 2014. DOI:10.3390/molecules19011344.
  [3] https://www.ltl-pharma.com/common/pdf/product/hypoca/hypoca15_capsule_siori_en.pdf
  [4] DEROSAGIUSEPPE. Barnidipine compared to lercanidipine in addition to losartan on endothelial damage and oxidative stress parameters in patients with hypertension and type 2 diabetes mellitus.[J]. BMC Cardiovascular Disorders, 2016. DOI:10.1186/s12872-016-0237-z.

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