2-Hydroxy-1,5-naphthyridine

Uses

Synthesis

27017-69-2

10261-82-2

The general procedure for the synthesis of 1,5-naphthyridin-2(1H)-one from the compound (CAS: 27017-69-2) was as follows: intermediate 2 (15.8 g) was dissolved in 6N hydrochloric acid solution (100 mL) and the reaction was stirred at 110 °C for 2 h. The reaction was carried out at 0 °C for 2 h. The reaction was carried out at 0 °C for 2 h. The solid was dried by suction filtration. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and the pH was adjusted to 6-7 with solid sodium hydroxide. the precipitated solid was separated by filtration and dried by suction with a sintered funnel for 2 h, followed by vacuum drying at 45 °C to afford the target product 1,5-naphthyridin-2(1H)-one (14.4 g, 98% yield). [ES MS] m/z 147 (MH+).

References