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Pipotiazine

Pipotiazine Structure
Pipotiazine
  • CAS No.39860-99-6
  • Chemical Name:Pipotiazine
  • CBNumber:CB9875298
  • Molecular Formula:C24H33N3O3S2
  • Formula Weight:475.67
  • MOL File:39860-99-6.mol
Pipotiazine Property
  • Boiling point 650.4±65.0 °C(Predicted)
  • Density 1.236±0.06 g/cm3(Predicted)
  • solubility Chloroform (Slightly), Methanol (Sparingly)
  • pka 15.10±0.10(Predicted)
  • form Solid
  • color Pale Yellow to Light Yellow
  • FDA UNII L903J9JPYV
  • ATC code N05AC04
Safety
  • Toxicity :LD50 in mice (mg/kg): 108 i.p.; 360 s.c.; 440 orally (Julou)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Pipotiazine Chemical Properties,Usage,Production

  • Originator Piportil, Rhone-Poulenc Rorer
  • Uses Pipotiazine is drug repurposing for Covid-19: discovery of potential small-molecule inhibitors of spike protein-ACE2 receptor interaction through virtual screening and consensus scoring.
  • Uses Antipsychotic.
  • Manufacturing Process 10-(3-Tetrahydropyranyloxypropyl)phenthiazine-2-sulfonic acid dimethylamide prepared by condensing 1-chloro-3-tetrahydropyranyloxy propane with phenthiazine-2-sulfonic acid dimethylamide (melting point 140°C) in xylene in the presence of sodamide.
    10-(3-Hydroxypropyl)phenthiazine-2-sulfonic acid dimethylamide was prepared by the action of hydrochloric acid in ethanol on 10-(3tetrahydropyranyloxypropyl)phenthiazine-2-sulfonic acid dimethylamide.
    10-(3-Methanesulphonyloxypropyl)phenthiazine-2-sulphonic acid dimethylamide, was obtained by condensing methanesulphonyl chloride in anhydrous pyridine with 10-(3-hydroxypropyl)phenthiazine-2-sulfonic acid dimethylamide.
    10-(3-Methanesulphonyloxypropyl)phenthiazine-2-sulfonic acid dimethylamide and 4-hydroxyethyl piperidine in toluene were heated under reflux with stirring. The reaction mixture was allowed to cool and water was added. The resulting toluene solution layer was decanted and washed twice with water. The toluene solution was then stirred with 5% hydrochloric acid. The hydrochloride of the desired phenthiazine base precipitated in gummy condition in the aqueous layer. This was decanted and treated with sodium hydroxide. It was then extracted three times with ethyl acetate. The extracts were dried over sodium sulfate, filtered and concentrated in vacuum. A resinous product was obtained. This product was dissolved in a mixture of benzene and cyclohexane and chromatographed on a column containing alumina. The chromatographed product was eluted successively with mixtures of benzene and cyclohexane and then with benzene and finally with a mixture of benzene and ethyl acetate. The eluates were evaporated to yield a crude product. This product was recrystallised from aqueous ethanol and yielded 10[3-[4-(2-hydroxyethyl)piperidyl]propyl]phenthiazine-2-sulfonic acid dimethylamide.
  • Therapeutic Function Neuroleptic
Pipotiazine Preparation Products And Raw materials
Raw materials
Preparation Products
Pipotiazine Suppliers
Global(20)Suppliers
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    AFINE CHEMICALS LIMITED
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  • Supplier： TargetMol Chemicals Inc.
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Pipotiazine Spectrum
39860-99-6, PipotiazineRelated Search:
  • 抑制剂
  • 化工原料
  • C24H33N3O3S2
  • 化合物 PIPOTIAZINE
  • 化合物 T34072
  • 哌泊噻嗪
  • 39860-99-6
  • Pipotiazinum
  • Pipotiazina
  • 19366 RP
  • Pipotiazine USP/EP/BP
  • 10H-Phenothiazine-2-sulfonamide, 10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-N,N-dimethyl-
  • 10-[3-[4-(2-Hydroxyethyl)piperidino]propyl]-N,N-dimethyl-10H-phenothiazine-2-sulfonamide
  • Pipotiazine (base and/or unspecified esters)
  • Pipothizaine
  • Pipotiazine
  • Pipothiazine

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