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Cetrorelix acetate

Cetrorelix acetate Property

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO:50.0(Max Conc. mg/mL);33.53(Max Conc. mM)
Water:2.0(Max Conc. mg/mL);1.34(Max Conc. mM)
Sequence Ac-3-(2-naphthyl)-D-Ala-4-Chloro-D-Phe-3(3-pyridyl)-D-Ala-Ser-Tyr-D-Cit-Leu-
CAS DataBase Reference 130143-01-0(CAS DataBase Reference)
FDA UNII W9Y8L7GP4C

Hazard and Precautionary Statements (GHS)

Cetrorelix acetate Chemical Properties,Usage,Production

Uses Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM[1].
Clinical Use Cetrorelix acetate is an analogue of GnRH with amino acid substitutions at residues 1, 2, 3, 6, and 10 and differing from ganirelix at amino acids 1, 6, and 8. Each of these substitutions are synthetic, non-DNA-directed amino acids and, like ganirelix acetate, impart GnRH antagonist activity to cetrorelix acetate. This drug also is marketed for use in women undergoing assisted reproductive therapy (ART) procedures, in which it is necessary to control their LH surge. This allows the follicles to develop to a size, as determined by ultrasound, that increases the success of timed insemination and oocyte retrieval for IVF. Like ganirelix acetate, cetrorelix acetate has an advantage over GnRH agonists, such as leuprolide acetate, because it reduces the fertility therapy cycle to days rather than weeks.
References [1] Beckers T et al. Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal Biochem. 1997 Aug 15;251(1):17-23. DOI:10.1006/abio.1997.2208
[2] Gründker C et al. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003 Oct 7;1:65. DOI:10.1186/1477-7827-1-65

Cetrorelix acetate Preparation Products And Raw materials

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Cetrorelix acetate Spectrum

130143-01-0, Cetrorelix acetateRelated Search:

130143-01-0
抑制剂
药物肽
优势产品
药物多肽
生物制药
多肽
蛋白质/多肽
医药原料药
C70H92ClN17O142C2H4O2
C70H92N17O14
CETRELIX ACETATE 醋酸西曲瑞克
(S)-N-((R)-1-氨基-1-氧代丙烷-2-基)-1-((2S,5S,8R,11S,14S,17R,20R,23R)-20-(4-氯苄基)-2-(3-胍基丙基)-11-(4-羟基苄基)-14-(羟基甲基)-5-异丁基-23-(萘-2-基甲基)-4,7,10,13,16,19,22,25-八氧代-17-(吡啶-3-基甲基)-8-(3-脲基丙基)-3,6,9,12,15,18,21,24-八氮杂二十六烷-1-酰基)吡咯烷-2-甲酰胺二乙酸盐
醋酸西曲瑞克API
二醋酸西曲瑞克
西曲瑞克二醋酸盐
熊去氧胆酸杂质
130143-01-0
Cetrorelix diacetate, 10 mM in DMSO
(S)-N-((R)-1-Amino-1-oxopropan-2-yl)-1-((2S,5S,8R,11S,14S,17R,20R,23R)-20-(4-chlorobenzyl)-2-(3-guanidinopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-5-isobutyl-23-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22,25-octaoxo-17-(pyridin-3-ylmethyl)-8-(3-ureidopropyl)-3,6,9,12,15,18,21,24-octaazahexacosan-1-oyl)pyrrolidine-2-carboxamide diacetate
SB-075 diacetate
NS-75A diacetate
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N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide diacetate