Chemical Properties
| form | Liquid |
| color | Colorless to light yellow |
Tigatuzumab Chemical Properties,Usage,Production
Uses
Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer[1].in vivo
Tigatuzumab (3 mg/kg; i.v. weekly for 4 weeks) effectively represses the tumor growth in human pancreatic cancer MIA PaCa-2-RFP orthotopic mouse model[1].
| Animal Model: | Nude mice with MIA PaCa-2-RFP human pancreatic cancer cells injection[1] |
| Dosage: | 3 mg/kg |
| Administration: | Intravenous injection; 3 mg/kg weekly for 4 weeks |
| Result: | Reduced the tumor volume and decreased the density of viable cancer cells in tumors. |
References
[1] Yamamoto J, et al. Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model. Cancer Lett. 2020 Nov 1;492:174-184. DOI:10.1016/j.canlet.2020.07.034Tigatuzumab Suppliers
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