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Cyclohexyl chloroformate

CAS No.13248-54-9
Chemical Name:Cyclohexyl chloroformate
CBNumber:CB9766031
Molecular Formula:C7H11ClO2
Formula Weight:162.61
MOL File:13248-54-9.mol

Cyclohexyl chloroformate Property

Boiling point 87.5℃
Density 1.14±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility Chloroform (Sparingly), Ethyl Acetate (Slightly)
form Oil
color Colourless
CAS DataBase Reference 13248-54-9(CAS DataBase Reference)
FDA UNII CFS37667DP
EPA Substance Registry System Carbonochloridic acid, cyclohexyl ester (13248-54-9)

Safety

Risk Statements :23/24/25-34
Safety Statements :26-36/37/39
RIDADR :3277

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H332-H335
Precautionary statements P261-P280-P305+P351+P338

Cyclohexyl chloroformate Chemical Properties,Usage,Production

Chemical Properties transparency liquid
Uses Cyclohexyl Chloroformate acts as a protecting group for amines and indoles in peptide synthesis.
Synthesis The Preparative Method of Cyclohexyl Chloroformate: a 1 L round-bottomed flask equipped with a delivery tube extending to the bottom of the flask, a pressure-equalizing addition funnel and a cold-finger condenser cooled with dry ice-acetone were placed in an ice bath. The exit tube of the condenser was connected to a CaCl2 drying tube and a suitable trap for phosgene and HCl. Phosgene was introduced into the flask until 109 g (1.1 mol) had been condensed. The reaction flask was stirred while 100 g (1 mol) of cyclohexyl alcohol was added through the dropping funnel at a rate to keep the mixture in gentle reflux for 1 h. The flask was allowed to stand at room temperature with stirring for 2 h. The solution was then concentrated under reduced pressure at room temperature to remove HCl and the excess phosgene. The residue may be used without further purification.
Precautions When stored for a prolonged period, it decomposes to CO2 and cyclohexyl chloride. Store in a refrigerator. Bottles may develop pressure and should be cooled before opening. Use in a fume hood. It is irritating to skin, eyes, and mucous membranes.
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