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BENZTHIAZIDE

BENZTHIAZIDE Structure
BENZTHIAZIDE
  • CAS No.91-33-8
  • Chemical Name:BENZTHIAZIDE
  • CBNumber:CB9758542
  • Molecular Formula:C15H14ClN3O4S3
  • Formula Weight:431.94
  • MOL File:91-33-8.mol
BENZTHIAZIDE Property
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :42/43
  • Safety Statements  :26-36
  • WGK Germany  :2
  • RTECS  :DK8400000
  • Hazardous Substances Data :91-33-8(Hazardous Substances Data)
  • Toxicity :LD50 in mice, rats (mg/kg): >5000, >10000 orally; 410, 422 i.v. (P'an)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H317-H334
  • Precautionary statements P261-P280-P342+P311
BENZTHIAZIDE Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: B7149
  • Product name : Benzthiazide
  • Purity: 
  • Packaging: 1G
  • Price: ₹2922.75
  • Updated: 2022/06/14
  • Buy: Buy

BENZTHIAZIDE Chemical Properties,Usage,Production

  • Originator Exna,Robins,US,1960
  • Uses Benzthiazide is a diuretic, antihypertensive agent.
  • Definition ChEBI: 7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema.
  • Manufacturing Process The preparation of the dihydro analog is as follows:
    (A) Preparation of 3-Chloromethyl-6-Chloro-7-Sulfamyl-3,4-DihydroBenzothiadizine-1,1-Dioxide - To 8 ml of 40-50% chloroacetaldehyde aqueous solution and 7 ml of dimethylformamide are added 10 grams of 2,4- disulfamyl-5-chloroaniline. The mixture is heated on a steam bath for 2 hours after which it is concentrated at reduced pressure. The residue is triturated with water. The solid material is recrystallized from methanol-ether after treatment with activated carbon to give 7.2 grams of product, MP 229°- 230°C.
    (B) Preparation of Benzylthiomethyl-6-Chloro-7-Sulfamyl-3,4- Dihydrobenzothiadiazine-1,1-Dioxide - A mixture of 3-(chloromethyl)-6-chloro- 7-sulfamyl-3,4-dihydrobenzothiadiazine-1,1-dioxide (0.02 mol) and benzylmercaptan (0.024 mol) in 20 ml of 10% sodium hydroxide and 20 ml of dimethylformamide is stirred at room temperature for 6 hours. After heating for 10 minutes on a steam bath, the mixture is cooled and acidified with 6 N HCl. The product, after recrystallization from acetone, melts at 210°-211°C.
  • brand name Aquatag (Solvay Pharmaceuticals); Fovane (Pfizer).
  • Therapeutic Function Diuretic, Antihypertensive
  • Safety Profile Poison by intravenous route. Adiuretic and antihypertensive agent. When heated todecomposition it emits very toxic fumes of SOx, NOx, andCl-.
BENZTHIAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BENZTHIAZIDE Suppliers
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BENZTHIAZIDE Spectrum
91-33-8, BENZTHIAZIDERelated Search:
  • Heterocyclic Compounds
  • S-Containing
  • Others
  • Heterocyclic Building Blocks
  • Chemical Synthesis
  • Building Blocks
  • AQUATAG
  • Sulfur & Selenium Compounds
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Aromatics
  • 抑制剂
  • 高端化学
  • 利尿药物
  • 小分子抑制剂
  • Building Blocks
  • Others
  • S-Containing
  • Heterocyclic Building Blocks
  • 43194
  • C15H14ClN3O4S3
  • 苄噻嗪,10 MM DMSO 溶液
  • 3-((苄硫基)甲基)-6-氯-2H-苯并[E][1,2,4]噻二嗪-7-磺酰胺1,1-二氧化物
  • 苄噻嗪BENZTHIAZIDE
  • 苄噻嗪 标准品
  • 苯并噻嗪
  • 苄噻嗪杂质
  • 苄噻嗪
  • 苄硫噻嗪
  • 苄硫醚氯噻嗪
  • 91-33-8
  • Benzthiazide, 10 mM in DMSO
  • Hydrochlorothiazide Impurity 31 (Benzthiazide)
  • Inhibitor,Carbonate dehydratase,Carbonic Anhydrase,Benzthiazide,inhibit
  • 3-((Benzylthio)methyl)-6-chloro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
  • BENZTHIAZIDE USP/EP/BP
  • Edemex
  • diucene
  • Diucen
  • Dihydrex
  • Benzothiazide
  • Aquatag
  • 6-chloro-7-sulfamoyl-3-benzylthiomethyl-2h-1,2,4-benzothiadiazine1,1-dioxide
  • 6-chloro-3-[[(phenylmethyl)thio]methyl]-2h-1,2,4-benzothiadiazine-7-sulfonamid
  • 6-chloro-3-(((phenylmethyl)thio)methyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide
  • 4or6-chloro-2-phenylphenol
  • 4-benzothiadiazine-7-sulfonamide,3-((benzylthio)methyl)-6-chloro-,1,1-2h-2
  • 3-benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine1,1-dioxide
  • 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
  • 3-benzylthiomethyl-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxi
  • 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 3-[(benzylthio)methyl]-6-chloro-7-sulfamoyl-2h-benzo-1,2,4-thiadiazine1,1-diox
  • 3-[(benzylthio)methyl]-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dio
  • 3-[(Benzylsulfanyl)methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 3-((benzylthio)methyl)-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dio
  • 3-((Benzylthio)methyl)-6-chloro-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(((phenylmethyl)thio)methyl

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