ChemicalBook Product Catalog Organic Chemistry Organic fluorine compound Naphthol as-e phosphate

Naphthol as-e phosphate

Product NameNaphthol as-e phosphate
CAS18228-17-6
CBNumberCB9737978
MFC17H13ClNO5P
MW377.72
EINECS242-106-1
MDL NumberMFCD00042718
MOL File18228-17-6.mol

Chemical Properties

Density	1.567±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: soluble
form	A crystalline solid
pka	1.04±0.30(Predicted)
color	White to light yellow
BRN	6664478
Major Application	histology
InChI	1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
InChIKey	RQAQWBFHPMSXKR-UHFFFAOYSA-N
SMILES	OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3

Safety

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
F	8-10-21
Storage Class	11 - Combustible Solids

Naphthol as-e phosphate Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich(India) 70485	250MG	₹5390.85	Naphthol AS-E phosphate suitable for histology	Buy

Naphthol as-e phosphate Chemical Properties,Usage,Production

Uses

Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis th at oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).

Biological Activity

Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.

in vitro

Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.

in vivo

Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.

target

Naphthol as-e phosphate Supplier

Target	Value
CREB ()

Supplier	Tel	Email	Country	ProdList	Advantage
A.J Chemicals	91-9810153283	sales@ajchem.in	New Delhi，India	6052	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com		32996	60
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com		32430	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com		10377	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn		6377	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com		49709	58
Nantong HI-FUTURE Biology Co., Ltd.	+86-18051384581	sales@chemhifuture.com		3122	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com		38999	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com		9896	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com		43302	58

Naphthol as-e phosphate Spectrum

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