ChemicalBook > CAS DataBase List > PPADS TETRASODIUM SALT

PPADS TETRASODIUM SALT

PPADS TETRASODIUM SALT Structure
PPADS TETRASODIUM SALT
  • CAS No.149017-66-3
  • Chemical Name:PPADS TETRASODIUM SALT
  • CBNumber:CB9729515
  • Molecular Formula:C14H14N3O12PS2
  • Formula Weight:511.38
  • MOL File:149017-66-3.mol
PPADS TETRASODIUM SALT Property
  • storage temp. −20°C
  • solubility H2O: >10 mg/mL
  • form solid
  • color red to orange
  • FDA UNII L6K2LJ9BJK
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

PPADS TETRASODIUM SALT Chemical Properties,Usage,Production

  • Uses PPADS is a P2 receptor antagonist, with IC50s of 68 nM (P2X1) and 214 nM (P2X3). PPADS acts as an ATP (nucleotide) mimetic and competes with ATP for its binding site on P2 receptors. PPADS is also a reversible competitive antagonist of the NAADP receptor. PPADS reverses nociceptive hypersensitivity and reduces the increased NO/NOS system and IL-1β in both peripheral and central steps of nervous system[1][2][3].
  • Definition ChEBI: An arenesulfonic acid that is pyridoxal 5'-phosphate carrying an additional 2,4-disulfophenylazo substituent at position 6.
  • Biological Activity A non-selective P2 purinergic antagonist. Blocks recombinant P2X 1 , P2X 2 , P2X 3 , P2X 5 (IC 50 = 1 - 2.6 μ M), native P2Y 2 -like (IC 50 ~ 0.9 mM), and recombinant P2Y 4 (IC 50 ~ 15 mM) receptors.
  • IC 50 p2x1 Receptor: 68 nM (IC50); P2X2 Receptor: 214 nM (IC50)
  • References [1] Billington RA, et al. PPADS is a reversible competitive antagonist of the NAADP receptor. Cell Calcium. 2007 Jun;41(6):505-11. DOI:10.1016/j.ceca.2006.10.002
    [2] Brown SG, et al. Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Drug Dev Res. 2001 Aug;53(4):281-291. DOI:10.1002/ddr.1197
    [3] Martucci C, et al. The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice. Pain. 2008 Jul;137(1):81-95. DOI:10.1016/j.pain.2007.08.017
PPADS TETRASODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
PPADS TETRASODIUM SALT Suppliers
Global(40)Suppliers
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：57505
  • Advantage：58
  • Supplier：
  • Tel：821-50328103-801<br/>18930552037
  • Email：3bsc@sina.com
  • Country：China
  • ProdList：15839
  • Advantage：69
  • Supplier： Ascent Scientific
  • Tel：4401179829988
  • Email：customerservice@ascentscientific.co.uk
  • Country：United Kingdom
  • ProdList：279
  • Advantage：60
  • Supplier： Abmole Bioscience Inc.
  • Tel：021-50967598<br/>02150967598
  • Email：sales@abmole.cn
  • Country：China
  • ProdList：4494
  • Advantage：58
PPADS TETRASODIUM SALT Spectrum
149017-66-3, PPADS TETRASODIUM SALTRelated Search:
  • Purinergics P2 receptor
  • Purinergics
  • 合成有机化合物配体
  • C14H14N3O12PS2
  • C14H10N3Na4O12PS
  • PPADS,P2 PURINERGIC RECEPTOR拮抗剂
  • PPADS四钠盐
  • 149017-66-3
  • PPADS, P2 purinergic receptor antagonist
  • PPADS tetrasodium sa
  • 4-[(2E)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonooxymethyl)pyridin-2-ylidene]hydrazinyl]benzene-1,3-disulfonicaci
  • 1,3-Benzenedisulfonic acid, 4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-
  • PPADS TETRASODIUM SALT
  • 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid
  • C13745
  • pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) tetrasodium salt
  • 4-[[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzenedisulfonic acid tetrasodium salt
  • pyridoxalphosphate-6-azophenyl-2’,4’-disulfonicacid
  • PPADS
  • PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM
  • PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA
  • PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULFONIC ACID TETRASODIUM SALT
  • 4-[[4-FORMYL-5-HYDROXY-6-METHYL-3-[(PHOSPHONOOXY)METHYL]-2-PYRIDINYL]AZO]-1,3-BENZENEDISULFONIC ACID TETRASODIUM

Home

My