ChemicalBook > CAS DataBase List > Boc-Dap-OH

Boc-Dap-OH

CAS No.73259-81-1
Chemical Name:Boc-Dap-OH
CBNumber:CB9715251
Molecular Formula:C8H16N2O4
Formula Weight:204.22
MOL File:73259-81-1.mol

Boc-Dap-OH Property

Melting point 210 °C (dec.)
alpha -5.5 º (c=1, acetic acid)
Boiling point 364.4±37.0 °C(Predicted)
Density 1.189±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility DMSO (Slightly, Heated, Sonicated), Water (Sparingly, Heated, Sonicated)
form Solid
pka 2.88±0.16(Predicted)
color White to Off-White
optical activity [α]20/D +5.5±1°, c = 1% in methanol: water (1:1)
BRN 4182136
InChI InChI=1S/C8H16N2O4/c1-8(2,3)14-7(13)10-5(4-9)6(11)12/h5H,4,9H2,1-3H3,(H,10,13)(H,11,12)/t5-/m0/s1
InChIKey KRJLRVZLNABMAT-YFKPBYRVSA-N
SMILES C(O)(=O)[C@H](CN)NC(OC(C)(C)C)=O
CAS DataBase Reference 73259-81-1(CAS DataBase Reference)
UNSPSC Code 12352209
NACRES NA.22

Safety

Safety Statements :24/25
WGK Germany :3
F :10
HazardClass :IRRITANT
HS Code :29241990

NFPA 704:

	1
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H314-H361-H335-H336-H225-H260
Precautionary statements P501-P223-P261-P270-P202-P240-P231+P232-P210-P233-P201-P243-P241-P242-P271-P264-P280-P370+P378-P335+P334-P308+P313-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P402+P404-P403+P235-P405

Boc-Dap-OH Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: 662836
Product name : (N-Boc-β-amino)-Ala-OH
Purity:
Packaging: 1G
Price: ₹3637.2
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich
Product number: 15402
Product name : Boc-Dap-OH
Purity: ≥98.0% (TLC)
Packaging: 1G
Price: ₹5845.5
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 15402
Product name : Boc-Dap-OH
Purity: ≥98.0% (TLC)
Packaging: 1G
Price: ₹5845.5
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich
Product number: 15402
Product name : Boc-Dap-OH
Purity: ≥98.0% (TLC)
Packaging: 5G
Price: ₹23847.48
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 15402
Product name : Boc-Dap-OH
Purity: ≥98.0% (TLC)
Packaging: 5G
Price: ₹23847.48
Updated: 2022/06/14
Buy: Buy

Boc-Dap-OH Chemical Properties,Usage,Production

Chemical Properties White powder
Uses Reactant for:
- Protein assembly directed by synthetic molecular recognition motifs
- Solid phase synthesis of gramicidin S cyclic analogs with antibiotic and hemolytic activities
- Synthesis of HCV protease inhibitor modified analogs
- Solid phase synthesis of peptidic V1a receptor agonists
- Directed peptide assembly at lipid-water interface
Uses (S)-3-amino-2-(tert-Butoxycarbonylamino)propionic acid (Boc-Dap-OH) is a derivative of amino acids, mainly used as an intermediate in organic synthesis and pharmaceutical chemistry, and can be used in the synthesis of peptide drug molecules and bioactive molecules.
Preparation The raw material was dissolved inabsolute ethanol (5 mL), and the reaction flask was immersed in a water bath at 25 C. To the alcoholicsolution, 10% palladium-carbon (22.9 mg) and 1,4-cyclohexadiene (10 equivalents with respect to4; 0.47 mL, 5.0 mmol) were added, and the mixture was allowed to react under magnetic stirringovernight. After filtration over a short pad of Celite 545, the solvent was evaporated under reducedpressure conditions, and the solid residue was partitioned in a 1:1 (v/v) H2O/EtOAc mixture (10 mL).The aqueous phase was separated, back extracted with EtOAc (3 10 mL), concentrated under reducedpressure conditions, and lyophilized.Finally, the target product Boc-Dap-OH is obtained.
Definition Boc-Dap-OH is an amino acid molecule that is a zwitterion. Therefore, the addition of a base is required to prepare a nucleophilic amino acid. It is commonly acts as a nucleophile to attack the acyl carbon.
reaction suitability reaction type: Boc solid-phase peptide synthesis