Description
ChemicalBook > CAS DataBase List > RO-31-8220

RO-31-8220

Description
RO-31-8220 Structure
RO-31-8220
  • CAS No.138489-18-6
  • Chemical Name:RO-31-8220
  • CBNumber:CB9711637
  • Molecular Formula:C25H23N5O2S
  • Formula Weight:457.55
  • MOL File:138489-18-6.mol
RO-31-8220 Property
  • storage temp. 2-8°C
  • solubility DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
    DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
    DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
    Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM)
  • form Red solid
  • color Red
  • biological source synthetic (organic)
  • Water Solubility water: 1mg/mL
    DMSO: 100mg/mL
  • FDA UNII 3JPC9J3C82
  • UNSPSC Code 12352202
  • NACRES NA.77
Safety
  • HS Code  :2933790090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
RO-31-8220 Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: R136
  • Product name : Ro 31-8220 methanesulfonate salt
  • Purity: solid
  • Packaging: 1MG
  • Price: ₹18380.85
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: R136
  • Product name : Ro 31-8220 methanesulfonate salt
  • Purity: solid
  • Packaging: 5MG
  • Price: ₹73296.08
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 557520
  • Product name : Ro-31-8220 - CAS 138489-18-6 - Calbiochem
  • Purity: A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC?? = 10 nM) over CaM kinase II (IC?? = 17 μM) and prote
  • Packaging: 500μG
  • Price: ₹14880.01
  • Updated: 2022/06/14
  • Buy: Buy

RO-31-8220 Chemical Properties,Usage,Production

  • Description Ro 31-8220 mesylate is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC with IC50 values of 5, 24, 14, 27, 24 and 23 nM, also inhibits MAPKAP -K1b, MSK1, S6K1 and GSK3β with IC50 of 3, 8, 15, 38 nM.
  • Uses Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.
  • General Description Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.
  • Biochem/physiol Actions Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.
  • in vivo

    Ro 31-8220 (6 mg/kg/d, s.c.) is well tolerated, and has half-life of 5.7 hours in mice. Ro 31-8220-treated MLP?/? mice show a dramatic rescue in fractional shortening after treatment for 6 weeks, but the WT mice shows no change[4].

  • IC 50 PKC-α: 5 nM (IC50); PKC-βII: 14 nM (IC50); PKC-βI: 24 nM (IC50); PKC-ε: 24 nM (IC50); PKC-γ: 27 nM (IC50); Rat Brain PKC: 23 nM (IC50); MAPKAP-K1b: 3 nM (IC50); MSK1: 8 nM (IC50); S6K1: 15 nM (IC50); GSK3β: 38 nM (IC50)
  • storage +4°C
RO-31-8220 Preparation Products And Raw materials
Raw materials
Preparation Products
RO-31-8220 Suppliers
Global(149)Suppliers
  • Supplier：
    career henan chemical co
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    TargetMol Chemicals Inc.
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    InvivoChem
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：support@targetmol.com
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RO-31-8220 Spectrum
138489-18-6, RO-31-8220Related Search:
  • inhibitor
  • TGF-beta/Smad
  • Inhibitors
  • TGF-beta
  • Smad
  • 医用原料
  • 药靶配体
  • 抑制剂
  • 小分子抑制剂，天然产物
  • C26H27N5O5S2
  • C25H23N5O2S
  • C25H23N5O2SCH4O3S
  • RO 31-8220 MESYLATE |CAS 138489-18-6
  • 化合物RO 31-8220 MESYLATE,10 MM DMSO 溶液
  • RO 31-8220 MESYLATE (BISINDOLYLMALEIMIDE IX),蛋白KINASE抑制剂
  • RO 31-8220 (PKC抑制剂)
  • RO 31-8220 甲磺酸盐
  • 3-(3-(4-(1-甲基-1H-吲哚-3-基)-2,5-二氧代-2,5-二氢-1H-吡咯-3-基)-1H-吲哚-1-基)丙基异硫脲甲磺酸盐
  • MK-7123, PS-291822
  • RO31-8220 MSOH盐
  • 双吲哚马来酰亚胺 IX 甲烷磺酸盐
  • 138489-18-6
  • Ro 31-8220 Mesylate, 10 mM in DMSO
  • Ro 31-8220 mesylate (Bisindolylmaleimide IX), Protein kinase inhibitor
  • 3-(3-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl carbamimidothioate
  • RO-31-8220 USP/EP/BP
  • Bisindolylmaleimide IX (Ro 31-8220 Mesylate)
  • CS-1132
  • RO 31-8220 METHANESULFONATE; BISINDOLYLMALEIMIDE IX MESYLATE;RO318220
  • 3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate
  • Ro-31-8220 - CAS 138489-18-6 - Calbiochem
  • Ro 31-8220/Ro318220
  • Ro 31-8220 Mesylat
  • Ro31-8220MsOH
  • Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1)
  • BisindolylMaleiMide IX . Methansulfonate [Ro 31-8220]
  • BisindolylMaleiMide IX Mesylate
  • BISINDOLYLMALEIMIDE IX METHANESULPHONATE SALT
  • 3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE
  • BISINDOLYLMALEIMIDE IX, METHANESULFONATE
  • RO-31-8220

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