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CONCANAMYCIN A

CONCANAMYCIN A Structure
CONCANAMYCIN A
  • CAS No.80890-47-7
  • Chemical Name:CONCANAMYCIN A
  • CBNumber:CB9696475
  • Molecular Formula:C46H75NO14
  • Formula Weight:866.09
  • MOL File:80890-47-7.mol
CONCANAMYCIN A Property
  • Melting point 179-180℃ (dichloromethane ethanol )
  • Boiling point 966.4±65.0 °C(Predicted)
  • Density 1.20±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility Soluble in DMSO
  • form Lyophilized solid
  • pka 12.46±0.70(Predicted)
  • color White
  • BRN 3560277
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
  • EWG's Food Scores 1
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :T+
  • Risk Statements  :26/27/28-36
  • Safety Statements  :26-36/37/39-45
  • RIDADR  :UN 3462 6.1/PG 2
  • WGK Germany  :3
  • RTECS  :CB9732000
  • F  :10-21
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :2941900000
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300+H310+H330-H319
  • Precautionary statements P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P305+P351+P338
CONCANAMYCIN A Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: C9705
  • Product name : Concanamycin A
  • Purity: ≥70% (HPLC)
  • Packaging: 25μG
  • Price: ₹20978.85
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C9705
  • Product name : Concanamycin A
  • Purity: ≥70% (HPLC)
  • Packaging: 0.1MG
  • Price: ₹58671.5
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 27689
  • Product name : Concanamycin A
  • Purity: from Streptomyces sp., ≥80% (HPLC)
  • Packaging: 50μG
  • Price: ₹28794.5
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 27689
  • Product name : Concanamycin A
  • Purity: from Streptomyces sp., ≥80% (HPLC)
  • Packaging: 250μG
  • Price: ₹63163.88
  • Updated: 2022/06/14
  • Buy: Buy

CONCANAMYCIN A Chemical Properties,Usage,Production

  • Description Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2?Inhibits cell surface expression of virus envelope glycoproteins.3?Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4?Inhibits autophagy by blocking lysosomal acidification.5
  • Uses Concanamycin A has been used:
    • as a lysosomal inhibitor in young and old fibroblasts
    • as a vacuolar-type H+-ATPase inhibitor in presynaptic vesicles
    • as a lysosomal acidification blocker in HepG2 hepatocytes cells

  • Uses Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins.
  • Definition ChEBI: A concanamycin in which the lactone ring contains 4 double bonds and is substituted by 4 methyl groups, 2 hydroxy groups, 2 methoxy groups and an ethyl group.
  • General Description Chemical structure: macrolide
  • Biological Activity Specific inhibitor of V-type (vacuolar) H + -ATPase that displays > 2000-fold selectivity over other H + -ATPases (IC 50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H + -ATPases and porcine P-type Na + ,K + -ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.
  • Biochem/physiol Actions Concanamycin A (ConA) inhibits acidification of organelles and perforin-mediated cytotoxicity. It is a vacuolar-type v-ATPase inhibitor. ConA possesses antiprotozoal and antineoplastic properties. It mediates inhibition of the negative factor (Nef) protein of the human immunodeficiency virus.
  • storage Store at -20°C
  • References 1) Nishihara?et al.?(1995),?Specific inhibitors if vacuolar type H(+)-ATPases induce apoptotic cell death; Biochem. Biophys, Res. Commun.,?212?255 2) Hong?et al. (2006),?Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells; J. Pharmacol. Exp. Ther.,?319?672 3) Muroi?et al.?(1993),?Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus; Cell Struct. Function,?18?139 4) Cashikar and Hanson (1987),?A cell-based assay for CD63-containing extracellular vesicles; PLoS One,?14?e0220007 5) Gradzka?et al.?(2018),?Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes; Cell Death Dis.,?9?529
CONCANAMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
CONCANAMYCIN A Suppliers
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CONCANAMYCIN A Spectrum
80890-47-7, CONCANAMYCIN ARelated Search:
  • 酶类
  • 抑制剂
  • 试剂盒-细胞分析试剂盒
  • 化合物
  • 生化试剂-蛋白质
  • 化工原料
  • 抗生素
  • 微生物代谢物
  • 其他生化试剂
  • 生化试剂
  • Antibiotics A to Z
  • Antibiotics A-F
  • Antibiotics
  • BioChemical
  • C46H75NO14
  • 刀豆霉素
  • 伴霉素A
  • 刀豆霉素A
  • 刀豆球蛋白A/刀豆凝集素A/伴刀豆球蛋白A/伴刀豆凝集素/刀豆凝集素A/刀豆球朊A/CONA
  • 伴刀球霉素A
  • 伴刀球霉素
  • 刀豆素A(> 95%,BR)
  • FOLIMYCIN刀豆素A
  • 80890-47-7
  • Folimycin, <i>Streptomyces</i> sp.
  • Canavalin A
  • FOLIMYCIN
  • CONCANAMYCIN A USP/EP/BP
  • Concanamycin A (Folimycin)
  • Oxacyclooctadeca-3,5,13,15-tetraen-2-one, 18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propen-1-yl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyl-, (3Z,5E,...
  • Concanamycin
  • Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem
  • FOLIMYCIN, STREPTOMYCES SPECIES
  • FOLIMYCIN, STREPTOMYCES SP
  • x4357b
  • antibioticx4357b
  • NSC 674620
  • FoliMycin, TAN 1323B
  • A,ConcanaMycin
  • ConcanaMycin A (high purity)
  • (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(AMinocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-Methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-Methylbutyl]-9-ethyl-8,10-
  • (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one
  • S-45A
  • Antibiotic S-45A
  • Antibiotic A661I
  • A661-I
  • concanamycin A from streptomyces species
  • CONCANAMYCIN A, STREPTOMYCES SP
  • CONCANAMYCIN A

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