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3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE

3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Structure
3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE
  • CAS No.567-01-1
  • Chemical Name:3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE
  • CBNumber:CB9676121
  • Molecular Formula:C21H34O3
  • Formula Weight:334.49
  • MOL File:567-01-1.mol
3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Property
  • storage temp. Store at -20°C
  • solubility ≤25mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
  • form crystalline solid
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Chemical Properties,Usage,Production

  • Description 3β,5α-THDOC is a neurosteroid. It inhibits seizures induced by pilocarpine, but not pentylenetetrazol (PTZ; ), in mice (ED50s = 45.9 and >100 mg/kg, respectively). 3β,5α-THDOC has been found in the urine of women during the third trimester of pregnancy.
  • Uses 3β,5α-Tetrahydrodeoxycorticosterone is a novel derivative of the steroid Dehydroepiandrosterone (DHEA), a known uncompetitive inhibitor of Glucose 6-Phosphate Dehydrogenase (G6PD). Studies have shown that 3β,5α-Tetrahydrodeoxycorticosterone may have potential function in the modulation of calcium and GABAA-gated chloride channel currents found in rat and guinea-pig neurons.
  • in vitro epiallopregnanolone showed no effects on the gaba-mediated chloride flux through several types of recombinant gaba receptors. epiallopregnanolone inhibited the allopregnanolone-stimulated gaba-mediated chloride flux through gabaa receptors. epiallopregnanolone antagonized the inhibitory effects of allopregnanolone and ethanol on the population spike in the ca1 region of the hippocampal brain slices [1]. epiallopregnanolone selectively blocked the allopregnanolone inhibition of the population spike in the rat hippocampal ca1[3].
  • in vivo in rats trained to discriminate either 0.8g/kg or 1.2 g/kg ethanol, 100 mg/kg epiallopregnanolone treatment decreased the maximum effect by 40% and 54% ethanol lever, respectively. epiallopregnanolone significantly decreased response rates when compared with control condition [1].
  • References [1] ginsburg b c, lamb r j. alphaxalone and epiallopregnanolone in rats trained to discriminate ethanol[j]. alcoholism: clinical and experimental research, 2005, 29(9): 1621-1629.
    [2] macdonald r l, olsen r w. gabaa receptor channels[j]. annual review of neuroscience, 1994, 17(1): 569-602.
    [3] wang m, bckstrm t, landgren s. epiallopregnanolone selectively blocks the allopregnanolone inhibition of the population spike in the rat hippocampal ca1[j]. acta physiologica scandinavica, 1999, 167(2): a5-a5.
3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Preparation Products And Raw materials
Raw materials
Preparation Products
3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Suppliers
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3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE Spectrum
567-01-1, 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONERelated Search:
  • 3-BETA,5-ALFA-TETRAHYDRODEOXYCORTICOSTERONE
  • 别孕烷-3Β,21-二醇-20-酮
  • 5Α-孕甾-3Β,21-二醇-20-酮
  • 3Β,21-二羟基-5Α-孕甾-20-酮
  • 567-01-1
  • 32,21-Dihydroxy-5±-pregnan-20-one-d4
  • 3β,5α-Tetrahydrodesoxycorticosterone
  • 5α-PREGNAN-3β, 21-DIOL-20-ONE
  • 3β,5α-THDOC
  • "3β,5a-Tetrahydrodeoxycorticosterone"
  • 1-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-7-hydroxy-9 a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]p henanthren-1-yl]-2-hydroxyethan-1-one
  • 3β,5α-Tetrahydrodeoxycorticosterone
  • 3-beta,5-alfa-Tetrahydrodeoxycorticosterone
  • 5-ALPHA-PREGNAN-3-BETA, 21-DIOL-20-ONE
  • 5-A-pregnane-3-B-21-diol-20-one
  • 3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE

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