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Dihydrostreptomycin

Dihydrostreptomycin Structure
Dihydrostreptomycin
  • CAS No.128-46-1
  • Chemical Name:Dihydrostreptomycin
  • CBNumber:CB9665040
  • Molecular Formula:C21H41N7O12
  • Formula Weight:583.59
  • MOL File:128-46-1.mol
Dihydrostreptomycin Property
  • Melting point >300 °C
  • Boiling point 641.09°C (rough estimate)
  • Density 1.3963 (rough estimate)
  • refractive index 1.6800 (estimate)
  • pka pKa 7.8 (Uncertain)
  • FDA 21 CFR 556.200
  • FDA UNII P2I6R8W6UA
  • ATC code S01AA15
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Dihydrostreptomycin Chemical Properties,Usage,Production

  • Description Dihydrostreptomycin was first synthesized by Parke Davis Co. in 1946by the reduction of streptomycin. Naturally occurring dihydrostreptomycin was found in the culture broth of Streptomyces humidus by Takeda Chemicals Industries in 1957. Its hydrochloride or sulfate is more easily crystallized and more stable under alkaline conditions than streptomycin. Dihydrostreptomycin has been used for therapy of tuberculosis, but because it has a higher ototoxicity than streptomycin its use is now restricted to animal therapy.
  • Originator Dihydrostrepto,MSD ,US,1948
  • Uses Antibacterial.
  • Definition ChEBI: Dihydrostreptomycin is a member of streptomycins.
  • Manufacturing Process Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), or by isolation from a fermentation process (Takeda).
  • brand name Abocillin;Biostrep;Complexobiotico;Diapenin 3;Diapenin balsamico;Diarrestival;Didromycin;Didrothenate;Dihydrocidan sulfato;Dihydrostreptofar;Diidro-pantostrept;Distreptopab;Dreiciclina balsamica;Dst;Entera-strept;Estreptoluy;Estreptosirup;Helle-strep-forte;Hp 48;Mastigun;Mixtencillin;Retromyopen;Rocopenstrep;Sanstrepto;Solmycin;Solvo-strept;Streptoduocin;Veticar;Veycil-as.
  • Therapeutic Function Antibiotic
  • World Health Organization (WHO) Dihydrostreptomycin, a derivative of the aminoglycoside antibiotic streptomycin with similar antibacterial activity, was first synthesized in 1947 and subsequently used in the treatment of tuberculosis and gram-negative infections. Preparations for systemic use have been widely withdrawn as a result of concern regarding their severe ototoxicity. Dihydrostreptomycin is poorly absorbed from the gastrointestinal tract. It remains available in oral preparations in some countries.
  • Safety Profile Poison by intravenous and intramuscular routes. Moderately toxic by subcutaneous and intraperitoneal routes. Human teratogenic effects by unspecified route: developmental abnormahties of the eye and ear. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A derivative of streptomycin; has anesthetic properties. When heated to decomposition it emits toxic fumes of NOx
Dihydrostreptomycin Preparation Products And Raw materials
Raw materials
Preparation Products
Dihydrostreptomycin Suppliers
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Dihydrostreptomycin Spectrum
128-46-1, DihydrostreptomycinRelated Search:
  • 氨基糖苷类抗生素
  • C21H41N7O12
  • 双氢链霉素(双氢链霉素硫酸盐)检测标准品
  • 化合物 T19806
  • 硫酸双氢霉素
  • 双氢霉素
  • 128-46-1
  • 1,-((1R,2R,3S,4S,5R,6S)-4-((2S,4S,5R)-3-((2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)tetrahyd
  • Dihydrostreptomycin USP/EP/BP
  • D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-
  • 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine
  • vibriomycin
  • dihydro-streptomyci
  • dhms
  • abiocine
  • D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1?4)-N,N-bis(aminoiminomethyl)-
  • DihydrostreptomycineSulphateSterileUsp26
  • dihydrostreptomycine sulphate
  • D-StreptaMine,O-2-deoxy-2-(MethylaMino)-a-L-glucopyranosyl-(1&reg
  • 4)-N1,N3-bis(aMinoiMinoMethyl)-
  • 2)-O-5-deoxy-3-C-(hydroxyMethyl)-a-L-lyxofuranosyl-(1&reg
  • DihydroestreptoMycin Sulfate
  • DHSM
  • 4-O-[2-O-[2-(Methylamino)-2-deoxy-α-L-glucopyranosyl]-5-deoxy-3-hydroxymethyl-α-L-lyxofuranosyl]-N,N'-bis(aminoiminomethyl)-D-streptamine
  • Benzimidazole, 2-cyanomethyl
  • Acetonitrile, 2-benzimidazolyl-
  • 2-[(1S,3R,4S,5R,6R)-5-(Diaminomethylideneamino)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylaminooxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-3,4,6-trihydroxycyclohexyl]guanidine
  • Dihydrostreptomycin (base and/or unspecified salts)
  • DIHYDROSTREPTOMYCIN

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