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Isoflupredone Acetate

Isoflupredone Acetate Structure
Isoflupredone Acetate
  • CAS No.338-98-7
  • Chemical Name:Isoflupredone Acetate
  • CBNumber:CB9500538
  • Molecular Formula:C23H29FO6
  • Formula Weight:420.47
  • MOL File:338-98-7.mol
Isoflupredone Acetate Property
  • Melting point 244-246° (dec)
  • alpha D23 +108° (c = 0.735 in dioxane)
  • Boiling point 576.5±50.0 °C(Predicted)
  • Density 1.32±0.1 g/cm3(Predicted)
  • storage temp. -20°C Freezer
  • solubility Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly), Ethanol (Slightly)
  • pka 12.05±0.70(Predicted)
  • form Solid
  • color White to Off-White
  • FDA UNII 55P9TUL75S
Safety
  • HS Code  :2937220000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H361
  • Precautionary statements P201-P202-P281-P308+P313-P405-P501

Isoflupredone Acetate Chemical Properties,Usage,Production

  • Uses Isoflupredone Acetate is an anti-inflammatory drug used in veterinary medicine. It is a corticosteroid with both glucocorticoid and mineralocorticoid activity and has been shown to increase the frequency of severe hypokalemia in healthy cows.
  • Definition ChEBI: 9alpha-Fluoro-11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate is a corticosteroid hormone.
  • Veterinary Drugs and Treatments Isoflupredone acetate is a potent glucocorticoid and like other glucocorticoids can be used for its antiinflammatory or immunosuppressive effects. Labeled indications for isoflupredone include: adjunctive treatment of bovine ketosis, alleviating pain and lameness associated with musculoskeletal conditions, acute hypersensitivity reactions, adjunctive treatment of overwhelming infections with severe toxicity, shock, supportive therapy in the treatment of stress conditions (e.g., surgery), dystocia, retained placenta, inflammatory ocular conditions, snakebite and parturient paresis.
    In horses, isoflupredone has been used parenterally to reduce inflammation associated with recurrent airway obstruction (RAO, “heaves”, COPD).
    While the drug could be used in small animals, it is recommended to use other glucocorticoid agents instead, where there has been more experience and other approved products for dogs and cats are available.
  • in vivo

    Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline.html" class="link-product" target="_blank">Oxytetracycline (HY-B0275)[2].

    Animal Model:96 weanling heifers (Bronchopneumonia was induced by intrabronchial infusion of Mannheimia haemolytica)[2]
    Dosage:0.05 mg/kg
    Administration:i.m.; on days 2 and 4 after the challenge
    Result:Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers. Prevented these reductions and resulted in faster clinical improvement when co-treated with Oxytetracycline (HY-B0275).
  • Toxics Screening Level The ITSL for Isoflupredone Acetate is 0.01 μg/m3 based on annual averaging.
Isoflupredone Acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Isoflupredone Acetate Suppliers
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Isoflupredone Acetate Spectrum
338-98-7, Isoflupredone AcetateRelated Search:
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  • 原料
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  • 338-98-7
  • 9-fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
  • Isoflupredone Acetate, 10 mM in DMSO
  • Nintedanib Impurity 156
  • 1, 4-PREGNADIEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE 21-ACETATE
  • 21-Acetoxy-9-fluoro-11b,17-dihydroxypregna-1,4-dienen-3,20-dione
  • 9-Fluoroprednisolone acetate(Isoflupredone acetate)
  • Isofluprednisone acetate
  • Isoflupredone Acetate (1348907)
  • Isoflupredone Acetate USP/EP/BP
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β)-
  • 9alpha-Fluoro-11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate
  • Isoflupredone Acetate USP
  • 2-((8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-diMethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
  • Predef R 2X
  • NSC 37977
  • NSC 12600
  • 9-Fluoroprednisolone-21-acetate
  • 21-Acetoxy-9-fluoro-
  • U-6013
  • 21-(Acetyloxy)-9α-fluoro-11β,17α-dihyroxypregna-1,4-diene-3,20-dione
  • 21-ACETOXY-9-FLUORO-11SS,17-DIHYDROXY-PREGNA-1,4-DIENE-3,20-DIONE
  • Isoflupredone acetate
  • 21-acetoxy-9-fluoro-11,17-dihydroxy-pregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11.beta.)-
  • 21-ACETOXY-9-FLUORO-11BETA,17-DIHYDROXY-PREGNA-1,4-DIENE-3,20-DIONE
  • IsoflupredineAcetate
  • 21-Acetoxy-9-fluoro-11,B-17-dihydroxy-pregna-1,4-diene-3,20-dione
  • isoflupredone 21-acetate
  • ISOFLUPREDONE ACETATE (200 MG)
  • predef
  • biorinil
  • 9-fluorprednisoloneacetate
  • 9-fluoroprednisoloneacetate
  • 9-alpha-fluoroprednisoloneacetate
  • 4-diene-3,20-dione,9-fluoro-11-beta,17,21-trihydroxy-pregna-21-acetate
  • 4-diene-3,20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-pregna-(11-be

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