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BRYOSTATIN 1

BRYOSTATIN 1 Structure
BRYOSTATIN 1
  • CAS No.83314-01-6
  • Chemical Name:BRYOSTATIN 1
  • CBNumber:CB9454936
  • Molecular Formula:C47H68O17
  • Formula Weight:905.03
  • MOL File:83314-01-6.mol
BRYOSTATIN 1 Property
  • Melting point 230-235°
  • alpha D25 +34.1° (c = 0.044 in methanol)
  • Boiling point 716.44°C (rough estimate)
  • Density 1.1245 (rough estimate)
  • refractive index 1.5940 (estimate)
  • storage temp. -20°C
  • solubility DMSO: soluble
  • pka 11.10±0.70(Predicted)
  • form solid
  • color white
  • optical activity +34.125 (methanol)
  • EWG's Food Scores 1
  • NCI Dictionary of Cancer Terms bryostatin 1
  • FDA UNII 37O2X55Y9E
  • NCI Drug Dictionary bryostatin 1
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :68
  • Safety Statements  :22-24/25-36/37
  • WGK Germany  :3
  • RTECS  :EH9455000
  • HS Code  :2932990090
  • Toxicity :LD50 in mice, rats (mg/kg): 0.038, 0.068 i.v. (Prendiville)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335-H373
  • Precautionary statements P271-P280-P312
BRYOSTATIN 1 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: B7431
  • Product name : Bryostatin 1
  • Purity: ≥99%, solid
  • Packaging: 10μG
  • Price: ₹22591.78
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 203811
  • Product name : Bryostatin 1 - CAS 83314-01-6 - Calbiochem
  • Purity: A macrocyclic lactone with antitumor properties.
  • Packaging: 10μG
  • Price: ₹18830
  • Updated: 2022/06/14
  • Buy: Buy

BRYOSTATIN 1 Chemical Properties,Usage,Production

  • Uses Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis in?mice. It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.
  • Definition ChEBI: A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoe hylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of br ostatins.
  • Biological Activity Protein kinase C (PKC) activator that binds with high affinity (K i = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents.
  • Biochem/physiol Actions Bryostatin 1 (Bry1) is a macrocyclic lactone. This synaptogenic compound is obtained from the marine bryozoan?Bugula neritina. Bry1 is capable of reversing synaptic loss. It can enable synaptic maturation in animal models with several neurological disorders. It possesses antidepressant activity, when administered intracebroventricularly. Bry1 is known to participate in protecting cell tight junctions (TJs), anti-inflammatory functions and immune regulation.
  • storage Store at -20°C
  • References [1]. gschwendt m, fürstenberger g, rose-john s, et al. bryostatin 1, an activator of protein kinase c, mimics as well as inhibits biological effects of the phorbol ester tpa in vivo and in vitro. carcinogenesis, 1988, 9(4): 555-562.
    [2]. stone rm, sariban e, pettit gr, et al. bryostatin 1 activates protein kinase c and induces monocytic differentiation of hl-60 cells. blood, 1988, 72(1): 208-213.
    [3]. schuchter lm, esa ah, may s, et al. successful treatment of murine melanoma with bryostatin 1. cancer res, 1991, 51(2): 682-687.
BRYOSTATIN 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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BRYOSTATIN 1 Spectrum
83314-01-6, BRYOSTATIN 1Related Search:
  • inhibitor
  • Serine/Threonine Kinase Activators
  • Protein Kinase C (PKC)
  • Protein Kinase ActivatorsSerine/Threonine Kinase Biology
  • Kinase/Phosphatase Biology
  • Cell Signaling and Neuroscience
  • 抑制剂
  • 对照品
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Serine/Threonine Kinase Activators
  • Protein Kinase C (PKC)
  • Kinase/Phosphatase Biology
  • C47H68O17
  • C47H68O1
  • BRYOSTATIN 1,蛋白KINASE C活化剂
  • 化合物 T14831
  • 苔藓抑素1
  • 83314-01-6
  • Bryostatin 1, protein kinase C activator
  • 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl ester, (2E,4E)-
  • Bryostatin 1 - CAS 83314-01-6 - Calbiochem
  • (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester
  • CS-1164
  • Byrostatin 1
  • (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-Methoxy-2-oxoethylidene)-10,10,26,26-tetraMethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-y
  • 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en
  • (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl2,4-octadienoicacidester
  • NSC-339555
  • (26R)-Bryostatin 1
  • bryostatin1,0
  • BRYOSTATIN
  • BRYO 1
  • BRYOSTATIN 1

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