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Chelidonic acid

Configuration Method

Chelidonic acid

CAS No.99-32-1
Chemical Name:Chelidonic acid
CBNumber:CB9441381
Molecular Formula:C7H4O6
Formula Weight:184.1
MOL File:99-32-1.mol

Chelidonic acid Property

Melting point 265 °C (dec.) (lit.)
Boiling point 238.02°C (rough estimate)
Density 1.4880 (rough estimate)
refractive index 1.5600 (estimate)
storage temp. 2-8°C
solubility DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
form Solid
pka 1.26±0.40(Predicted)
color Gray to brown
Water Solubility 14.3g/L(25 ºC)
Merck 13,2060
BRN 163607
InChIKey PBAYDYUZOSNJGU-UHFFFAOYSA-N
LogP -0.746 (est)
CAS DataBase Reference 99-32-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII T33U4W5K6O
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36
WGK Germany :3
RTECS :UP7350000
HS Code :29329990

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P305+P351+P338

Chelidonic acid Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: 382272
Product name : Chelidonic acid
Purity: 98%
Packaging: 5G
Price: ₹10456.95
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 382272
Product name : Chelidonic acid
Purity: 98%
Packaging: 25G
Price: ₹39543.73
Updated: 2022/06/14
Buy: Buy

Chelidonic acid Chemical Properties,Usage,Production

Configuration Method Chelidonic acid is supplied as a crystalline solid. A stock solution may be made by dissolving thechelidonic acid in the solvent of choice, which should be purged with an inert gas. Chelidonic acid is soluble in the organic solvent DMSO at approximately 1 mg/ml concentration. Chelidonic acid is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers,chelidonic acid should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Chelidonic acid has a solubility of approximately 0.14 mg/ml in a 1:6 solution of DMSO: PBS(pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Uses Chelidonic acid is suitable for use a in homogeneous preparation of native dihydrodipicolinate synthase from pea. It may be used as endocyclic oxygen-containing ligand in the synthesis of aqua[bis(2-pyridylmethyl)amine][chelidonato(1.5-)]-copper(II) chelidonate(0.5-) monohydrate.
Definition ChEBI: Chelidonic acid is a carbonyl compound and a member of pyrans.
General Description Chelidonic acid (CA) is a γ-pyrone. It is reported as constituent of the rhizome of Chelidonium majus L. It has many pharmacological effects, such as mild analgesic and antimicrobial effects. Therapeutic potential of CA for the treatment of intestinal inflammation has been investigated. CA is reported as inhibitor of the rat brain glutamate decarboxylase. Biosynthesis of CA in cell suspension cultures of Leucojum aestivum has been studied.
in vivo
Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice^[3].
IC 50 NF-κB; Caspase-1; Glutamate decarboxylase: 1.2 μM (Ki)
Purification Methods The acid crystallises from aqueous EtOH. Dry it first at 100o/2hours, then at 160o to constant weight to remove water of crystallisation. It decarboxylates at 220-230o in a vacuum. [Riegel & Zwilgmeyer Org Synth Coll Vol II 126 1943, Beilstein 18 H 490, 18/8 V 646.]