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4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Structure
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
  • CAS No.39793-31-2
  • Chemical Name:4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
  • CBNumber:CB9349944
  • Molecular Formula:C7H5NO2S
  • Formula Weight:167.19
  • MOL File:39793-31-2.mol
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Property
  • Melting point 180 °C
  • Boiling point 437.4±25.0 °C(Predicted)
  • Density 1.609
  • storage temp. Sealed in dry,2-8°C
  • solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 2 mg/ml
  • form Beige solid
  • pka 4.36±0.30(Predicted)
  • color Light brown to gray
  • UNSPSC Code 12352200
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: 760250
  • Product name : 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid
  • Purity: 97%
  • Packaging: 500MG
  • Price: ₹6657.38
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 138000
  • Product name : D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem
  • Purity: The D-Amino Acid Oxidase Inhibitor, also referenced under CAS 39793-31-2, controls the biological activity of D-Amino Acid Oxidase.
  • Packaging: 50MG
  • Price: ₹7070
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 138000
  • Product name : D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem
  • Purity: The D-Amino Acid Oxidase Inhibitor, also referenced under CAS 39793-31-2, controls the biological activity of D-Amino Acid Oxidase.
  • Packaging: 50MG
  • Price: ₹7070
  • Updated: 2022/06/14
  • Buy: Buy

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

  • Uses DAO-IN-2 is a novel D-amino acid oxidase (DAO) inhibitor. DAO-IN-2 demonstrates moderate potency for DAO in vitro and ex vivo[1].
  • Synthesis Reference(s) Journal of the American Chemical Society, 79, p. 2556, 1957 DOI: 10.1021/ja01567a053
  • General Description A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 μM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 μM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
  • References [1] Tim Sparey, et, al. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett. 2008,18, 11. DOI:10.1016/j.bmcl.2008.04.020
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Suppliers
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4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Spectrum
39793-31-2, 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACIDRelated Search:
  • 定制类
  • 高端化学
  • 合成材料中间体
  • 双杂环
  • C7H5NO2S
  • 79793-31-2
  • D-AMINO ACID OXIDASE INHIBITOR CALBIOCHEM
  • 4H-噻吩并[3,2-B]吡咯-5-甲酸
  • 4H-噻吩并[3,2-B]吡咯-5-甲酸,97%
  • 噻唑并[3,2-B]吡咯-5-甲酸
  • 4H-噻吩并[3,2-B]吡咯-5-羧酸
  • 4H-噻吩并[2,3-D]吡咯-5-羧酸
  • 4H-噻唑[3,2-B]吡咯-5-甲酸
  • 39793-31-2
  • DAO-IN-2
  • 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid (6CI, 7CI, 9CI, ACI)
  • 4-Thieno[3,2-b]pyrrole-5-carboxylic acid
  • 79793-31-2
  • D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem
  • CHEMBRDG-BB 4012315
  • AKOS BB-9991
  • 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
  • D-Amino Acid Oxidase Inhibitor
  • 4H-thieno[2,3-d]pyrrole-5-carboxylic acid
  • Thieno[2,3-b]pyrrole-5-carboxylic acid
  • 4H-thieno[3,2-b]pyrrole-5-carboxylic acid(SALTDATA: FREE)

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