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Neuraminidase

CAS No.9001-67-6
Chemical Name:Neuraminidase
CBNumber:CB9348886
Molecular Formula:NULL
Formula Weight:0
MOL File:Mol file

Neuraminidase Property

Density 1.00 g/mL at 20 °C
storage temp. 2-8°C
form lyophilized powder
color white
biological source Vibrio cholerae
Water Solubility Soluble in water or 10mM phosphate buffer, pH 6.0
Specific Activity 8-24units/mg protein (Lowry, using NAN-lactose)
EWG's Food Scores 1
EPA Substance Registry System Neuraminidase (9001-67-6)
UNSPSC Code 12352204
NACRES NA.54

Safety

Safety Statements :22-24/25
RIDADR :UN3373 - class 6.2 Biological substance, Category B
WGK Germany :3
RTECS :QQ3450000
F :3-10
TSCA :Yes

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H290-H315-H319-H335
Precautionary statements P234-P261-P264-P271-P302+P352-P305+P351+P338

Neuraminidase Price More Price(27)

Brand: Sigma-Aldrich(India)
Product number: N7885
Product name : Neuraminidase from Vibrio cholerae
Purity: Type III, buffered aqueous solution, 0.2 μm filtered, 1-5?units/mg protein (Lowry, using NAN-lactose)
Packaging: 1UNIT
Price: ₹15251.4
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: N8271
Product name : α(2→3,6,8,9) Neuraminidase from Arthrobacter ureafaciens
Purity: recombinant, expressed in E. coli, buffered aqueous solution
Packaging: 0.2UNIT
Price: ₹62670.6
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: N7885
Product name : Neuraminidase from Vibrio cholerae
Purity: Type III, buffered aqueous solution, 0.2 μm filtered, 1-5?units/mg protein (Lowry, using NAN-lactose)
Packaging: 2UNITS
Price: ₹27261.6
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: N5631
Product name : Neuraminidase from Clostridium perfringens (C. welchii)
Purity: Type VIII, lyophilized powder, 10-20?units/mg protein (using 4MU-NANA), 3.5-8.0?units/mg protein (mucin)
Packaging: 1UNIT
Price: ₹15406.8
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: N5631
Product name : Neuraminidase from Clostridium perfringens (C. welchii)
Purity: Type VIII, lyophilized powder, 10-20?units/mg protein (using 4MU-NANA), 3.5-8.0?units/mg protein (mucin)
Packaging: 5UNITS
Price: ₹49816.8
Updated: 2022/06/14
Buy: Buy

Neuraminidase Chemical Properties,Usage,Production

Uses Neuraminidase is used as a hydrolytic enzyme that removes sialic acid from mucoproteins, used in a study to assess binding with human T lymphocytes in sheep pretreated with neuraminidase. It has also been used in a study to investigate the effect of bile salts on the action of hydrolysis by neuraminidase.
Uses Neuraminidase is an important deglycosylation enzyme capable of cleaving all non-reducing unbranched N-acetylneuraminic and N-glycolylneuraminic acid residues by hydrolysis of α(2→6), α(2→3), α(2→8), and α(2→9) linkages (affinity in the order given). Branched sialic acids may also be cleaved with the use of high concentrations of enzyme and prolonged incubations. Desialylated glycoproteins may then be further characterized by treatment with various exoglycosidases resulting in partial or complete O-deglycosylation. SDS-PAGE and MALDI-TOF MS are typically utilized in purification, structural analysis, and sequencing process. These techniques also remove heterogeneity and charge from the glycoprotein.
Uses Neuraminidase from Vibrio cholera has been used in a study to describe a five-step purification method. It has also been used in a study to investigate modification of leukemia L1210 tumor cells.
General Description Neuraminidase enzymes are glycoside hydrolase enzymes that catalyze hydrolysis of terminal sialic acid residues. The most well-known are the viral nearamidases, which promote influenza virus release.
Biochem/physiol Actions Vibrio cholerae neuraminidase has been shown to promote cholera toxin infection by binding the toxin and aiding in its uptake by cells.