Manufacturing Process
2 Methods of producing of acetyl salicylic acid ester of N-acetyl-paminophenol:
1. 65.0 g of N-acetyl-p-aminophenol were slurried with 400 ml of water and
cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly added to the
mixture with stirring, the temperature being maintained 10°-15°C. To the
solution obtained, 75.0 g of acetyl salicylic chloride were added with vigorous
stirring over a period of 0.5 h, the solution being maintained at a temperature of about 10°C. Towards the end of the reaction the pH was checked and
adjusted to greater than 10 by the addition of a small amount of 20% sodium
hydroxide. After all the acid chloride had been added, vigorous stirring was
continued for 0.5 h during which time the crude product separated out. The
acetyl salicylic acid ester of N-acetyl-p-aminophenol was filtered off, washed
thoroughly with water and recrystallised from ethanol.
2. 65.0 g of sodium N-acetyl-p-aminophenol were slurried with 500.0 g of dry
benzene and 80.0 g of acetyl salicylic chloride added. The mixture was heated
under reflux for 4 h and filtered hot. The excess benzene was removed under
vacuum and the crude acetyl salicylic acid ester of N-acetyl-p-aminophenol
crystallized from ethanol.
Therapeutic Function
Analgesic, Antineuralgic, Antirheumatic, Antipyretic
