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(S)-(+)-2-Amino-3-methyl-1-butanol

CAS No.2026-48-4
Chemical Name:(S)-(+)-2-Amino-3-methyl-1-butanol
CBNumber:CB9319657
Molecular Formula:C5H13NO
Formula Weight:103.16
MOL File:2026-48-4.mol

(S)-(+)-2-Amino-3-methyl-1-butanol Property

Melting point 30-34 °C
alpha 16 º (c=10,EtOH)
Boiling point 81 °C8 mm Hg(lit.)
Density 0.926 g/mL at 25 °C(lit.)
refractive index n20/D 1.4548(lit.)
Flash point 196 °F
storage temp. Store at +2°C to +8°C.
solubility DMSO (Slightly), Methanol (Slightly)
pka 12.82±0.10(Predicted)
form Liquid After Melting
color Clear slightly yellow
optical activity [α]25/D +10°, c = 10 in H2O
Water Solubility Soluble in water.
Sensitive Air Sensitive
BRN 1719137
InChIKey NWYYWIJOWOLJNR-RXMQYKEDSA-N
CAS DataBase Reference 2026-48-4(CAS DataBase Reference)
FDA UNII R54N4NJ3ZZ
NIST Chemistry Reference (S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)
UNSPSC Code 12352104
NACRES NA.22

Safety

Hazard Codes :Xi
Risk Statements :36-36/37/38
Safety Statements :26-24/25-36
WGK Germany :3
F :10-23
HazardClass :IRRITANT
HS Code :29221980

NFPA 704:

	2
2		1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319
Precautionary statements P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313

(S)-(+)-2-Amino-3-methyl-1-butanol Price More Price(9)

Brand: Sigma-Aldrich
Product number: 186708
Product name : (S)-(+)-2-Amino-3-methyl-1-butanol
Purity: 96%
Packaging: 1G
Price: ₹2598
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 186708
Product name : (S)-(+)-2-Amino-3-methyl-1-butanol
Purity: 96%
Packaging: 1G
Price: ₹2598
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 8.14082
Product name : (S)-(+)-2-Amino-3-methyl-1-butanol
Purity: for synthesis
Packaging: 1ML
Price: ₹3650
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich
Product number: 186708
Product name : (S)-(+)-2-Amino-3-methyl-1-butanol
Purity: 96%
Packaging: 5G
Price: ₹10002.3
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 186708
Product name : (S)-(+)-2-Amino-3-methyl-1-butanol
Purity: 96%
Packaging: 5G
Price: ₹10002.3
Updated: 2022/06/14
Buy: Buy

(S)-(+)-2-Amino-3-methyl-1-butanol Chemical Properties,Usage,Production

Chemical Properties white to light yellow crystal powde
Uses (S)-(+)-2-Amino-3-methyl-1-butanol can be used to prepare:
- Imines and oxazolines by reacting with aldehydes and nitriles, respectively.
- Chiral oxazoline derived multidentate ligands containing cyclophosphazene moiety.
Uses L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.
Purification Methods Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]