Synthesis
In dextroketoprofen were added anhydrous ethanol, ethyl acetate and aminobutanetriol, the weight ratio of dextroketoprofen: anhydrous ethanol: ethyl acetate: aminobutanetriol = 1: 2: 7: 0.48, stirring, reflux for 30 minutes, filtered to the crystallization tank while still hot, condensate to 28 ~ 32 , open ice brine down to 10 below the static 3 hours, centrifugation, the cake was washed 2 times with 1 wt. anhydrous ethanol and 7 wt. ethyl acetate mixed solution, centrifugation, filtrate distillation recovery, the cake was dried at 50 for 10 hours, crushed, that is, the dextroketoprofen. The filter cake is washed with 1 wt. of anhydrous ethanol and 7 wt. of ethyl acetate mixed solution for 2 times, centrifugation, filtrate distillation and recovery, the filter cake is dried at 50 for 10 hours, crushed, that is, the finished product of dextroketoprofen aminobutanetriol.
