ChemicalBook > CAS DataBase List > Poly(1-vinylpyrrolidone-co-vinyl acetate)

Poly(1-vinylpyrrolidone-co-vinyl acetate)

CAS No.25086-89-9
Chemical Name:Poly(1-vinylpyrrolidone-co-vinyl acetate)
CBNumber:CB9295023
Molecular Formula:C10H15NO3
Formula Weight:197.23
MOL File:25086-89-9.mol

Poly(1-vinylpyrrolidone-co-vinyl acetate) Property

Density 1.27 g/mL at 25 °C(lit.)
Tg 108
refractive index 1.4300 to 1.4380
Flash point 72 °F
solubility Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
form powder
color White
Viscosity 800.0 to 3000.0 mPa-s
Stability Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
InChI InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
InChIKey FYUWIEKAVLOHSE-UHFFFAOYSA-N
SMILES C(N1CCCC1=O)=C.O(C=C)C(=O)C
LogP 0.370 (est)
Indirect Additives used in Food Contact Substances POLY(VINYL ACETATE-CO-VINYLPYRROLIDONE)
FDA UNII D9C330MD8B
EPA Substance Registry System Vinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi,F
Risk Statements :10-36/37/38-67-36-11-22
Safety Statements :22-24/25-36/37/39-26-16
RIDADR :UN 1987 3/PG 2
WGK Germany :1
RTECS :AH3539000
TSCA :TSCA listed
HazardClass :3
PackingGroup :II
HS Code :29349990
Toxicity :LD50 orl-rat: >630 mg/kg JACTDZ 2(5),141,83

NFPA 704:

	3
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H319-H336
Precautionary statements P210-P261-P305+P351+P338

Poly(1-vinylpyrrolidone-co-vinyl acetate) Price More Price(6)

Brand: Sigma-Aldrich(India)
Product number: 190845
Product name : Poly(1-vinylpyrrolidone-co-vinyl acetate)
Purity: average Mw ~50,000 (GPC vs. poly(ethylene oxide)), powder
Packaging: 250G
Price: ₹14527.15
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 190837
Product name : Poly(1-vinylpyrrolidone-co-vinyl acetate) solution
Purity: average Mw ~13,000 (GPC vs. poly(ethylene oxide)), 50?wt. % in isopropanol
Packaging: 500G
Price: ₹9396.1
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P0385
Product name : Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 3:7) (50% in Ethanol)
Purity:
Packaging: 25G
Price: ₹2400
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P0385
Product name : Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 3:7) (50% in Ethanol)
Purity:
Packaging: 500G
Price: ₹6800
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P0382
Product name : Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 7:3) (50% in Ethanol)
Purity:
Packaging: 25G
Price: ₹2200
Updated: 2022/05/26
Buy: Buy

Poly(1-vinylpyrrolidone-co-vinyl acetate) Chemical Properties,Usage,Production

Chemical Properties Copovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste.
Chemical Properties white powder
Uses Copovidone is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches.
Uses Poly(1-vinylpyrrolidone-co-vinyl acetate)
Production Methods Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.
General Description ～1:2.4 mole ratio of VP:VA
Pharmaceutical Applications Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.
Safety Profile Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx.
Safety Copovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin. A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.
LD₅₀ (rat, oral): >0.63 g/kg
Solubility in organics Acetone, chloroform, methanol, THF, water
Solubility in organics THF (above 68C)
Solubility in organics THF, water
storage Copovidone is stable and should be stored in a well-closed container in a cool, dry place.
Incompatibilities Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.
Regulatory Status Copovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).