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Bulleyaconitine A

Bulleyaconitine A Structure
Bulleyaconitine A
  • CAS No.107668-79-1
  • Chemical Name:Bulleyaconitine A
  • CBNumber:CB9291737
  • Molecular Formula:C35H49NO9
  • Formula Weight:627.76
  • MOL File:107668-79-1.mol
Bulleyaconitine A Property
  • Boiling point 690.9±55.0 °C(Predicted)
  • Density 1.28±0.1 g/cm3(Predicted)
  • storage temp. Store at 2-8°C
  • solubility DMSO: 125 mg/mL (199.12 mM)
  • form Solid
  • pka 13.12±0.70(Predicted)
  • color White to off-white
  • FDA UNII 7VFN6Z3BRE
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H330-H300
  • Precautionary statements P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501

Bulleyaconitine A Chemical Properties,Usage,Production

  • Description Bulleyaconitine A is an aconitine-type two terpene alkaloid, and its molecular formula is C35H49NO10.?As early as 1980, bulleyaconitine was separated and extracted from a traditional analgesic and anti-inflammatory herb in the west of Yunnan called dianxi dula (or dianxi wutou) (Aconitum bulleyanum Diels), by the Kunming Institute of Botany, Chinese Academy of Sciences . At present, bulleyaconitine A can be separated from Aconitum plants, for example, dianxi wutou (Aconitum bulleyanum Diels), cujing wutou (Aconitum crassicaule W.T.?Wang), changhui wutou (Aconitum georgei Comber), and zhiyuan wutou (Aconitum transsectum Diels).
  • Physical properties Appearance: white powder. Solubility: soluble in methanol, ethanol, chloroform, and ether; insoluble in water; and easily dissolved in dilute hydrochloric acid or dilute sulfuric acid . Melting point: 160–165?°C
  • History In 1983, it was confirmed that bulleyaconitine A shows obvious analgesic and antiinflammatory effects by preclinical pharmacological tests . Clinical trials were carried out in 29 hospitals in 9 provinces in 1984. Bulleyaconitine A passed technical appraisals in May 1985 and was first formally put into production by Yunnan Honghe Pingbian pharmaceutical company, where it obtained the trade name “Bulleyaconitine A.” Bulleyaconitine A has been listed into the Pharmacopoeia of the People’s Republic of China (2015). In recent years, bulleyaconitine A has shown a great market growth and competitive power, owing to its exact curative effect and rapid clinical promotion in chronic disease and rheumatic immune disease.
  • Uses Bulleyaconitine A is an agent that expresses long-lasting local anaesthetic properties used in the treatment of chronic pain and arthritis. Commonly used in China as a traditional medicine.
  • Pharmacology 1. Anti-inflammatory and analgesic effect. Bulleyaconitine A plays a significant anti-inflammatory effect by inhibiting the release of prostaglandins. The analgesic effect may be related to the rivalry of 5-HT and the inhibition of inflammatory chemokines in the brain, because inhibition of PGE2 release may lead to disinhibition of β-endorphin . Further studies showed that bulleyaconitine A achieved the analgesic effect by effectively reducing sodium ion current, the electrophysiological basis on which pain conduction is dependent . Zhanguo Niu et?al. found that bulleyaconitine A could be used to treat mild and moderate burn pain, with less adverse reactions and no addiction . Thus, bulleyaconitine A may be suitable for long-term use as a choice of analgesic therapy for burn pain. Recently, through clinical observation on the effect of bulleyaconitine A treatment in acute gouty arthritis, some scholars discovered that bulleyaconitine A brought about good effect and could effectively improve the clinical symptoms of patients by taking 0.4?mg bulleyaconitine A orally three times in daily .
    2. Immune regulation. Bulleyaconitine A has obvious inhibitory effects to immune cells involved in joint inflammation, which may have a close relationship to its clinical anti-inflammatory effect. Ye Lu et?al. studied the influence of bulleyaconitine A on partial immune functions of BALB/c mice and found that 0.32?mg/kg bulleyaconitine A inhibits some immune functions of BALB/c mice . Moreover, it was reported that bulleyaconitine A significantly inhibited the phagocytic function and the ability to secrete nitric oxide (NO) of macrophages .
    3. Other pharmacological effects. An injection of 0.1 mg/kg bulleyaconitin A in fasting rat can inhibit the formation of corneal neovascularization induced by alkali burn . Bulleyaconitine A also has local anesthesia and antipyretic effect. Besides, bulleyaconitine A can be used for the treatment of lumbar muscle strain, scapulohumeral periarthritis, and sprain of limbs.
  • Clinical Use 1. Rheumatic immune disease. Since listing, bulleyaconitine A has been applied in clinical treatment for rheumatoid arthritis and osteoarthritis, receiving good curative effects.
    2. Chronic pain. Bulleyaconitine A does not belong to NSAID, and it exerts its effects by regulating the sodium ion channel. So there is little psychological dependence and organ toxicity, avoiding gastrointestinal/cardiovascular/renal adverse reactions and drug dependence or other potential dangers caused by NSAID and opioid analgesics.
Bulleyaconitine A Preparation Products And Raw materials
Raw materials
Preparation Products
Bulleyaconitine A Suppliers
Global(205)Suppliers
  • Supplier：
    career henan chemical co
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  • Email：sales@coreychem.com
  • Country：China
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    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
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  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32222
  • Advantage：58
Bulleyaconitine A Spectrum
107668-79-1, Bulleyaconitine ARelated Search:
  • reference standards from Chinese medicinal herbs (TCM).
  • phytochemical
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  • C35H49NO9
  • 79572-91-9
  • 草乌甲素,10 MM DMSO 溶液
  • 草乌甲素A
  • 草乌甲素(对照品)
  • 乌头碱A
  • 来源于草乌
  • 大头乌头碱甲
  • 草乌甲素, 来源于草乌
  • BULLEYACONITINE A 草乌甲素
  • 草乌甲素 20MG
  • 草乌甲素(标准品)
  • 草乌甲素
  • 107668-79-1
  • Bulleyaconitine A, 10 mM in DMSO
  • Bulleyaconitine A-RM
  • (-)-Syringaresinol 4-O-β-D-glucopyranosi
  • Bulleyaconitine A USP/EP/BP
  • Methanone, [(1α,6α,14α,16β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl) aconitan-14-yl](4-methoxyphenyl)-
  • crassicauline A(bulleyaconitine
  • Bulleyaconitine A, 98%, from Aconitum kusnezoffii Rchb.
  • ((1-α,6-α,14-α,16-β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-methanone
  • Bulleyaconitine
  • Methanone, [(1a,6a,14a,16b)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)-
  • Aconitane,Methanone deriv
  • BULLEYACONITINE A(RG)

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