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Terazosin hydrochloride

Terazosin hydrochloride Structure
Terazosin hydrochloride
  • CAS No.63074-08-8
  • Chemical Name:Terazosin hydrochloride
  • CBNumber:CB9285510
  • Molecular Formula:C19H26ClN5O4
  • Formula Weight:423.9
  • MOL File:63074-08-8.mol
Terazosin hydrochloride Property
  • Melting point 261-263°C
  • storage temp. Inert atmosphere,2-8°C
  • solubility H2O: 25 mg/mL
  • form powder
  • color white to off-white
  • Water Solubility Soluble in water at 20mg/ml. Also soluble in methanol or ethanol.
  • Stability Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
  • CAS DataBase Reference 63074-08-8(CAS DataBase Reference)
  • NCI Dictionary of Cancer Terms terazosin hydrochloride
  • FDA UNII 8QOP8Z9955
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P501
Terazosin hydrochloride Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: T4680
  • Product name : Terazosin hydrochloride
  • Purity: ≥98% (TLC), powder
  • Packaging: 50MG
  • Price: ₹21390.2
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T4680
  • Product name : Terazosin hydrochloride
  • Purity: ≥98% (TLC), powder
  • Packaging: 250MG
  • Price: ₹91427.95
  • Updated: 2022/06/14
  • Buy: Buy

Terazosin hydrochloride Chemical Properties,Usage,Production

  • Description Terazosin hydrochloride is a highly water-soluble antihypertensive agent with a structure and profile closely related to that of prazosin.
  • Originator Abbott (USA)
  • Uses An α-1-adrenergicblocker related to prazosin.
  • Uses Hytrin (Abbott).
  • Uses Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies5. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods6.
  • brand name Terazosin is INN and BAN;HEITRIN.
  • General Description Terazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride (Hytrin), is a structuralcongener of prazosin hydrochloride. It possessessimilar selective properties of specifically inhibiting 1-adrenergic receptors. The drug is slightly less potent thanprazosin hydrochloride. Terazosin hydrochloride has a halflifeof approximately 12 hours, which is much longer thanthat of prazosin. This lends itself to a once-daily dose tocontrol hypertension in many patients.
  • Biological Activity α 1 - and α 2B -adrenoceptor antagonist (K i values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α 1A , α 1B , α 1D , α 2B , α 2A and α 2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo .
  • Biochem/physiol Actions α1-adrenoceptor antagonist.
  • storage Store at RT
  • References References/Citations 1) Hancock et al. (1995), Actions of terazosin and its enantiomers at subtypes of alpha-1 and alpha-2 adrenoceptors in vitro; Recept. Signal Transduct. Res., 15 863 2) Kyncl et al. (1986), Pharmacology of terazosin; Am. J. Med., 80 12 3) Shionoiri et al. (1994), Long-term therapy with terazosin may improve glucose and lipid metabolism in hypertensives: a multicenter prospective study; Am. J. Med. Sci., 307 Suppl 1 S91 4) Pan et al. (2003), Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells; J. Urol., 169 724 5) Chen et al. (2015), Terazosin activates Pgk1 and HSP90 to promote stress resistance; Nat. Chem. Biol., 11 19
Terazosin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Terazosin hydrochloride Suppliers
Global(263)Suppliers
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    SIMAGCHEM CORP
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  • Supplier：
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  • Email：marketing@targetmol.com
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Terazosin hydrochloride Spectrum
63074-08-8, Terazosin hydrochlorideRelated Search:
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  • Adrenoceptor
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