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CATHEPSIN D

CATHEPSIN D Structure
CATHEPSIN D
  • CAS No.9025-26-7
  • Chemical Name:CATHEPSIN D
  • CBNumber:CB9265367
  • Molecular Formula:NULL
  • Formula Weight:0
  • MOL File:Mol file
CATHEPSIN D Property
  • storage temp. -20°C
  • form lyophilized powder
  • color white
  • biological source human
  • Water Solubility Reconstitute in water at 1µg/µl
  • Specific Activity ≥250units/mg protein (E1%/280)
  • FDA UNII MF0G4WBC26
  • UNSPSC Code 12352204
  • NACRES NA.32
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
CATHEPSIN D Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: C3138
  • Product name : Cathepsin D from bovine spleen
  • Purity: lyophilized powder, ≥2.0?units/mg protein
  • Packaging: 5UNITS
  • Price: ₹25086
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C3138
  • Product name : Cathepsin D from bovine spleen
  • Purity: lyophilized powder, ≥2.0?units/mg protein
  • Packaging: 10UNITS
  • Price: ₹41436.3
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C3138
  • Product name : Cathepsin D from bovine spleen
  • Purity: lyophilized powder, ≥2.0?units/mg protein
  • Packaging: 20UNITS
  • Price: ₹82650.6
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C8696
  • Product name : Cathepsin D from human liver
  • Purity: lyophilized powder, ≥250?units/mg protein (E1%/280)
  • Packaging: 25μG
  • Price: ₹32667.3
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C3138
  • Product name : Cathepsin D from bovine spleen
  • Purity: lyophilized powder, ≥2.0?units/mg protein
  • Packaging: 40UNITS
  • Price: ₹153990.3
  • Updated: 2022/06/14
  • Buy: Buy

CATHEPSIN D Chemical Properties,Usage,Production

  • Uses Cathepsin D, human liver is useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture. It contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. It is a useful prognostic indicator for breast cancer.
  • Uses Cathepsin D from human liver has been used:
    • in β-secretase activity assay
    • for enzymatic degradation of amyloid β 1-42
    • in microinjection of human foreskin fibroblasts

  • General Description Cathepsin D is an aspartic protease, which is located in lysosomes. It is involved in protein catabolism and maintains hormone and antigen processing. Cathepsin D is implicated in neoplasia and neurodegenerative changes. It regulates lysosomal proteolysis and endogenous fibrinolysis.
  • Biochem/physiol Actions Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
  • Purification Methods Cathepsin D is purified on a CM column after (NH4)2SO4 fractionation and dialysis, then starch-gel electrophoresis and by ultracentrifugal analysis. Finally chromatograph on a DEAE column [Press et al. Biochem J 74 501 1960].
CATHEPSIN D Preparation Products And Raw materials
Raw materials
Preparation Products
CATHEPSIN D Suppliers
Global(40)Suppliers
  • Supplier：
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  • Supplier： Sigma-Aldrich
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CATHEPSIN D Spectrum
9025-26-7, CATHEPSIN DRelated Search:
  • 抗体-一抗
  • Cathepsins and Granzymes
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Enzymes
  • BioChemical
  • Apoptosis and Cell Cycle
  • CATHEPSIN D蛋白
  • CTSD蛋白
  • 组织蛋白酶D 来源于牛脾脏
  • ANTI-CATHEPSIN D ANTIBODY-组织蛋白酶D轻链抗体
  • 生化酶
  • 组织蛋白酶D(人体肝脏)
  • 组织蛋白酶D
  • 9025-26-7
  • Native Bovine Cathepsin D
  • Native Human Cathepsin D
  • Cathepsin D from Human, recombinant
  • Cathepsins D
  • CATHEPSIN D FROM BOVINE SPLEEN
  • CATHEPSIN D, FROM HUMAN LIVER
  • EC 3.4.23.5
  • EC 3.4.22.5
  • CATHEPSIN D, HUMAN SPLEEN
  • CATHEPSIN D, HUMAN LIVER
  • CATHEPSIN D, HUMAN
  • CATHEPSIN D, BOVINE SPLEEN
  • CATHEPSIN D, BOVINE KIDNEY
  • CATHEPSIN D, BOVINE
  • CATHEPSIN D

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