ChemicalBook > CAS DataBase List > 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Structure
4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-
  • CAS No.913822-46-5
  • Chemical Name:4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-
  • CBNumber:CB92627097
  • Molecular Formula:C29H23N7O2S2
  • Formula Weight:565.67
  • MOL File:913822-46-5.mol
4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Property
  • Density 1.483±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
  • form powder
  • pka 9.11±0.10(Predicted)
  • color white to beige
  • UNSPSC Code 12352200
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335-H400-H410
  • Precautionary statements P261-P264-P270-P271-P273-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P391-P403+P233-P405-P501
4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML2382
  • Product name : SC75741
  • Purity: ≥97% (HPLC)
  • Packaging: 5MG
  • Price: ₹6420
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML2382
  • Product name : SC75741
  • Purity: ≥97% (HPLC)
  • Packaging: 25MG
  • Price: ₹25920
  • Updated: 2022/06/14
  • Buy: Buy

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Chemical Properties,Usage,Production

  • Description SC-75741 is an inhibitor of NF-κB (EC50 = 0.1 μM in an NF-κB reporter gene assay). It inhibits replication of human, avian, and swine influenza virus strains in MDCK cells in a concentration-dependent manner. It also reversibly inhibits replication of H5N1 and H7N7 avian influenza virus strains in human A549 cells. In vivo, SC-75741 (15 mg/kg, i.p.) reduces viral mRNA and production of IL-6 and CXCL10/IP-10 in the lungs of H5N1 infected mice. SC-75741 is also protective against H5N1 and H7N7 infection in mice when administered for 7 days prior to or up to 4 days post infection.
  • Uses SC75741 is a potent NF-κB inhibitor with EC50.
  • in vivo

    SC75741 (intraperitoneal injection; 15 mg/kg; for 2 days) leads to a reduced propagation of the H5N1 virus mRNA by 90% in the lungs of infected mice[2].
    The plasma-levels of SC74751 (intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; for 3.5 and 6 hours) after i.v. administration decreases mono-exponentially and half-life is roughly 40 min. After i.p. administration, elimination of SC75741 seems to be limited by a slow uptake from the peritoneum and a half-life of 55 min is observed[1].

    Animal Model:Inbred female C57BL/6 mice at the age of 6-8 weeks[2]
    Dosage:15?mg/kg
    Administration:Intraperitoneal injection; for 2 days
    Result:Reduced the amount of viral mRNA by 90%.
    Animal Model:Inbred female C57BL/6 mice at the age of 6-8 weeks[1]
    Dosage:5 mg/kg or 15 mg/kg
    Administration:Intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; 3.5 and 6 hours
    Result:Half-life was roughly 40 min and 55 min for i.v. and i.p. administration, respectively.
  • target NF-κB
  • IC 50 p65: 200 nM (IC50)
4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Spectrum
913822-46-5, 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-Related Search:
  • Inhibitors
  • 抑制剂
  • 药靶配体
  • 小分子抑制剂，天然产物
  • C29H23N7O2S2
  • 化合物SC75741,10 MM DMSO 溶液
  • 化合物 SC75741
  • N-(6-苯甲酰基-1H-苯并[D]咪唑-2-基)-2-(1-(噻吩并[3,2-D]嘧啶-4-基)哌啶-4-基)噻唑-4-甲酰胺
  • N-(6-苯甲酰基-1H-苯并咪唑-2-基)-2-(1-噻吩并[3,2-D]嘧啶-4-基-4-哌啶基)-4-噻唑甲酰胺
  • 913822-46-5
  • SC75741, 10 mM in DMSO
  • 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- USP/EP/BP
  • CS-2697
  • 75741
  • N-(6-Benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide
  • V 1810
  • SC75741
  • 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-

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