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Voriconazole-d3

Voriconazole-d3 Structure
Voriconazole-d3
  • CAS No.188416-29-7
  • Chemical Name:Voriconazole-d3
  • CBNumber:CB92610550
  • Molecular Formula:C16H14F3N5O
  • Formula Weight:349.31
  • MOL File:188416-29-7.mol
Voriconazole-d3 Property
  • Boiling point 508.6±60.0 °C(Predicted)
  • Density 1.42±0.1 g/cm3(Predicted)
  • pka 11.54±0.29(Predicted)
  • form Solid
  • color White to off-white
  • FDA UNII USG4B1CD29
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Voriconazole-d3 Chemical Properties,Usage,Production

  • Description Voriconazole-d3 is an Ergosterol biosynthesis inhibitor and a labeled form of Voriconazole. This mono triazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible for the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.
  • Uses Voriconazole is a triazole antifungal agent used primarily in the treatment or prevention of aspergillosis and candidal infections. However, its therapy may cause transient, asymptomatic serum aminotransferase elevations, and it is also a well-known cause of acute drug-induced liver injury.
  • Application Voriconazole-d3 is derived from 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone, which is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis.
  • References 1. Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species DOI:10.1128/AAC.41.8.1840
    Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776
    2. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp
    Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278
    3. In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens
    Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946
Voriconazole-d3 Preparation Products And Raw materials
Raw materials
Preparation Products
Voriconazole-d3 Suppliers
Global(76)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
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Voriconazole-d3 Spectrum
188416-29-7, Voriconazole-d3Related Search:
  • 主打产品
  • 化学试剂
  • 系列1
  • 伏立康唑中间体
  • (2R,3S/2S,3R)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-基)-1-(1H-1,2,4-TRIAZOL-1-YL)-2-BUTANOL
  • (2R,3S/2S,3R)-2-(2,4-二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-
  • 伏立康唑EP杂质D、伏立康唑右旋体
  • 化合物 (±)-VORICONAZOLE
  • (2R,3S/2S,3R) -2-(2,4-二氟苯基)-3-(5-氟-4-嘧啶基) -1-(1H-1,2,4-三唑-1-基) -丁-2醇
  • ()-伏立康唑-D3
  • (2S,3R)-REL-2-(2,4-二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇
  • (R,S)-Α-(2,4-二氟苯基)-5-氟-Β-甲基-Α-(1H-1,2,4-三唑-1-甲基)-4-嘧啶乙醇
  • (R*,S*)-Α-(2,4-二氟苯基)-5-氟-Β-甲基-Α-(1H-1,2,4-三唑-1-甲基)-4-嘧啶乙醇
  • 4-三唑-1-基甲基)-4-嘧啶乙醇
  • 4-二氟苯基)-5-氟-Β-甲基-Α-(1H-1
  • (R*,S*)3-(5-氟嘧啶-4-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇
  • (R*,S*)-Α-(2,4-二氟苯基)-5-氟-Β-甲基-Α-(1H-1,2,4-三唑-1-基甲基)-4-嘧啶乙醇
  • 伏立康唑中间体II
  • 188416-29-7
  • (±)-Voriconazole
  • (2RS,3SR)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
  • Fluconazole Intermediate 2
  • Intermediate 2 of voriconazole
  • Voriconazole Intermediate II
  • VORICONAZOLE-D3
  • (2R, 3S/2S, 3R)-3-(5-Fluoropyrimidin-4-yl)-2-(2,4-difluorophyenyl)-1-(1H-1,2,4 triazol-1-yl) butan-2-ol {Racemic Voriconazole}
  • 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-rel-
  • (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)ChemicalBook
  • 4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)
  • 4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1
  • 3R)-2-(2
  • (2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
  • (R *, S *) 3- (5-fluoropyrimidin-4-yl) -2- (2,4-difluorophenyl) -1- (1H-1,2,4-triazol-1-yl ) -2-butanol
  • (2R,3R)-Voriconazole
  • Voriconazole PI-6
  • (2S,3R)-rel-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
  • (2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
  • (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)

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