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6-METHOXY-2-NAPHTHYLACETIC ACID

CAS No.23981-47-7
Chemical Name:6-METHOXY-2-NAPHTHYLACETIC ACID
CBNumber:CB9249046
Molecular Formula:C13H12O3
Formula Weight:216.23
MOL File:23981-47-7.mol

6-METHOXY-2-NAPHTHYLACETIC ACID Property

Melting point 170-172°C
Boiling point 408.8±20.0 °C(Predicted)
Density 1.235
RTECS QJ1045000
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Off-white solid.
pka 4.35±0.30(Predicted)
color Off-White to Yellow
FDA UNII 9H7K3YOD7Q
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xn,Xi,N
Risk Statements :22-36/37/38-37/38-41-50
Safety Statements :26-39-61
HS Code :2916399090

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P301+P312+P330-P305+P351+P338

6-METHOXY-2-NAPHTHYLACETIC ACID Price More Price(2)

Brand: Sigma-Aldrich
Product number: 08137
Product name : 2-(6-Methoxynaphthalen-2-yl)acetic acid
Purity: pharmaceutical impurity standard
Packaging: 50MG
Price: ₹55445.65
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 08137
Product name : 2-(6-Methoxynaphthalen-2-yl)acetic acid
Purity: pharmaceutical impurity standard
Packaging: 50MG
Price: ₹55445.65
Updated: 2022/06/14
Buy: Buy

6-METHOXY-2-NAPHTHYLACETIC ACID Chemical Properties,Usage,Production

Chemical Properties Yellow Solid
Uses A metabolite of Nabumetone. A competitive, non-selective COX inhibitor.
Definition ChEBI: (6-methoxy-2-naphthyl)acetic acid is a monocarboxylic acid consisting of 2-naphthylacetic acid having a methoxy substituent at the 6-position. The active metabolite of the prodrug nabumetone. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a drug metabolite and a xenobiotic metabolite. It is a monocarboxylic acid and a methoxynaphthalene. It is functionally related to a 2-naphthylacetic acid.
Biological Activity 6-methoxy naphthalene acetic acid is a competitive and non-selective cox inhibitor with ki values of 21 and 19 μm for ovine cox-1 and -2, respectively [1][2][3].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].6-methoxy naphthalene acetic acid (6-mna) is a competitive and non-selective cox inhibitor with ki values of 21 and 19 μm for ovine cox-1 and -2, respectively [1][2]. 6-mna is a metabolite of nebumetome. 6-mna inhibited human recombinant cox-1 and -2 with ic50 values of 70 and 20 μm, respectively [1].
References [1]. barnett j, chow j, ives d, et al. purification, characterization and selective inhibition of human prostaglandin g/h synthase 1 and 2 expressed in the baculovirus system. biochim biophys acta. 1994 nov 16;1209(1):130-9.
[2]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[3]. laneuville o1, breuer dk, dewitt dl, et al. differential inhibition of human prostaglandin endoperoxide h synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. j pharmacol exp ther. 1994 nov;271(2):927-34.