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R(+)-BAY K 8644

R(+)-BAY K 8644 Property

Safety

NFPA 704:

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319
Precautionary statements P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

R(+)-BAY K 8644 Chemical Properties,Usage,Production

Description BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.
Uses (R)-(+)-Bay K 8644 is a Ca2+ channel inhibitor, whose enantiomer is a Ca2+ channel activator.
Definition ChEBI: (R)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (R)-configuration. It is an enantiomer of a (S)-Bay-K-8644.
Biological Activity L-type Ca 2+ -channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ) and (S)-(-)- enantiomer ((4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester ). In combination with BIX-01294, helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs).
storage Store at +4°C

R(+)-BAY K 8644 Preparation Products And Raw materials

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R(+)-BAY K 8644 Spectrum

98791-67-4, R(+)-BAY K 8644Related Search:

Calcium channel
抑制剂
药靶配体
细胞生物学试剂
(R)-2,6-二甲基-5-硝基-4-(2-(三氟甲基)苯基)-1,4-二氢吡啶-3-甲酸甲酯
(4R)-1,4-二氢-2,6-二甲基-5-硝基-4-[2-(三氟甲基)苯基]-3-吡啶羧酸甲酯
化合物(R)-(+)-BAY K 8644
钙离子通道抑制剂(BAY-K-8644 ((R)-(+)-))
98791-67-4
(R)(+)BayK8644,(R) (+) Bay K 8644
(+)-BAY-K-8644
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-, methyl ester, (4R)-
(+)-methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate
BAY-K-8644 ((R)-(+)-);R-4407;NI-105;(+)-BAY-K-8644
Bay-K-8644 ((R)-(+)-)
NI 105
BAY-k 4407
R-4407
BAY-r-4407
[4R,(+)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester
r-(+)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
(4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester
R(+)-BAY K 8644 98% 0 C
(+/-)-BAY K 8644, 0 TO 5 °C
R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE
R(+)-BAY K 8644
R-(+)-1,4-DIHYDRO-2,6-DIMETHY-5-NITRO-(2-[TRIFLUOROMETHYL]-PHENYL)-3-PYRIDINE CARBOXYLIC ACID METHYL ESTER
(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER