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PROGLUMETACIN MALEATE

PROGLUMETACIN MALEATE Structure
PROGLUMETACIN MALEATE
  • CAS No.57132-53-3
  • Chemical Name:PROGLUMETACIN MALEATE
  • CBNumber:CB9188310
  • Molecular Formula:C46H58ClN5O8
  • Formula Weight:844.43
  • MOL File:57132-53-3.mol
PROGLUMETACIN MALEATE Property
  • solubility DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
  • form Solid
  • color White to Pale Yellow
  • FDA UNII FV919079LU
  • ATC code M01AB14
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

PROGLUMETACIN MALEATE Chemical Properties,Usage,Production

  • Uses Proglumetacin Dioxalate is a new non-steroidal anti-inflammatory drug.
  • Definition ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropy -alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretor effects that helps prevent injury to the stomach lining.
  • Synthesis The reaction of N-benzoyl-N_x0002_, N_x0002_-di-n-propyl-dl-isoglutamin (proglumide) with 1-(3-chloropropyl)-4-(2-hydroxyethyl)-piperazine obtained from 1-(2-hydroxyethyl)piperazine and 1-bromo-3-chloropropane by means of sodium methanolate in DMSO at 105?C gives N--N_x0002_-(2-hydroxyethyl) piperazine, which is then condensated with Indomethacin (1-(p-chlorobenzoyl)- 5-methoxy-2-methylindole-3-acetic acid) by means of dicyclohexylcabodiimide and NaHCO3 in ethyl acetate .
    Synthesis_57132-53-3
  • in vivo

    Proglumetacin (Sprague-Dawley rats, 0-30 mg/kg, Orally, once) dose-dependently inhibits accumulation of pouch exudate[1].

    Animal Model:Sprague-Dawley rats (6 weeks)
    Dosage:0, 0.3, 3, 9, 30 mg/kg
    Administration:Orally, once
    Result:Caused dose-dependent reduction of leukocyte migration into the pouch exudate, caused 49.2% inhibition at 30 mg/kg; and markedly decreased the prostaglandin E2 content of the pouch exudate, but tended to increase the leukotriene B 4 content.
PROGLUMETACIN MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
PROGLUMETACIN MALEATE Suppliers
Global(23)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
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  • Supplier： J & K SCIENTIFIC LTD.
  • Tel： 18210857532
  • Email：jkinfo@jkchemical.com
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  • Supplier： Capot Chemical Co., Ltd
  • Tel：+86 (0) 571 85 58 67 18
  • Email：sales@capotchem.com
  • Country：China
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  • Supplier： Pure Chemistry Scientific Inc.
  • Tel：001-857-928-2050 or 1-888-588-9418
  • Email：sales@chemreagents.com
  • Country：United States
  • ProdList：10186
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PROGLUMETACIN MALEATE Spectrum
57132-53-3, PROGLUMETACIN MALEATERelated Search:
  • C46H58ClN5O8
  • 59209-48-4
  • 1-(4-氯苯甲酰基)-5-甲氧基-2-甲基1H-吲哚-3-乙酸 2-[4-[3-[[4-(苯甲酰基氨基)-5-(二丙氨基)-1,5-二氧戊基]氧基]丙基]-[1-哌嗪基]乙基酯
  • 普各洛美他辛
  • 57132-53-3
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester, (+-)-
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester (9CI)
  • Proglumetacine
  • PROGLUMETACIN MALEATE
  • PROGLUMETACIN

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