Synthesis
The general procedure for synthesizing 2-amino-5-iodobenzotrifluoride from 1-(trifluoromethyl)-1,2-phenyliodonyl-3(1H)-one and p-iodoaniline is as follows: in this embodiment, p-iodoaniline was used as the aromatic amine, and the rest of the reaction conditions and post-processing steps were the same as in Example 28. The specific reaction conditions were as follows: 1-(trifluoromethyl)-1,2-phenyliodono-3(1H)-one (0.5 mmol, 1.0 eq.), p-iodoaniline (1.5 mmol, 3.0 eq.), nickel hydroxide (10 μmol), and potassium carbonate (1.5 mmol, 3.0 eq.) were used as bases, and DMSO (2 mL) was used as a solvent, and the temperature of the reaction was 35 °C. The reaction time was 2 hours. After the reaction was completed, post-treatment was carried out according to the method of Example 1.
References
[1] Organic Letters, 2018, vol. 20, # 13, p. 3732 - 3735
[2] Patent: CN108503552, 2018, A. Location in patent: Paragraph 0240-0244
[3] Patent: CN103553857, 2016, B. Location in patent: Paragraph 0021-0022
[4] Organic Letters, 2014, vol. 16, # 6, p. 1768 - 1771
