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LEUPEPTIN HEMISULFATE MONOHYDRATE

LEUPEPTIN HEMISULFATE MONOHYDRATE Structure
LEUPEPTIN HEMISULFATE MONOHYDRATE
  • CAS No.55123-66-5
  • Chemical Name:LEUPEPTIN HEMISULFATE MONOHYDRATE
  • CBNumber:CB9135839
  • Molecular Formula:C20H38N6O4
  • Formula Weight:426.55
  • MOL File:55123-66-5.mol
LEUPEPTIN HEMISULFATE MONOHYDRATE Property
  • Boiling point 541.98°C (rough estimate)
  • Density 1.1865 (rough estimate)
  • refractive index 1.6000 (estimate)
  • RTECS YV4205100
  • pka 13.44±0.46(Predicted)
  • form Powder
  • FDA UNII J97339NR3V
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H312-H332-H341
  • Precautionary statements P201-P261-P280-P304+P340-P405-P501a

LEUPEPTIN HEMISULFATE MONOHYDRATE Chemical Properties,Usage,Production

  • Uses Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].
  • Definition ChEBI: Leupeptin is a tripeptide composed of N-acetylleucyl, leucyl and argininal residues joined in sequenceby peptide linkages. It is an inhibitor of the calpains, a family of calcium-activated proteases which promote cell death. It has a role as a serine protease inhibitor, a bacterial metabolite, a cathepsin B inhibitor, a calpain inhibitor and an EC 3.4.21.4 (trypsin) inhibitor. It is a tripeptide and an aldehyde. It is a conjugate base of a leupeptin(1+).
  • Safety Profile Questionable carcinogen withexperimental neoplastigenic data. When heated todecomposition it emits toxic fumes of NOx.
  • in vivo

    Leupeptin (0, 9, 18, 36 mg/kg; i.p.; single) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction[2].

    Animal Model:C57BL/6NCrl male mice (6-8 weeks old, 20-25 g)[1].
    Dosage:0, 9, 18, 36 mg/kg
    Administration:Intraperitoneal injection; single
    Result:Promoted the accumulation of LC3b-II in mouse liver.
  • References [1] Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68. DOI:10.7164/antibiotics.22.558
    [2] Fu L, et al. Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs. mBio. 2021 Oct 26;12(5):e0222021. DOI:10.1128/mBio.02220-21
    [3] Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7(6):629-42. DOI:10.4161/auto.7.6.15100
    [4] Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.
LEUPEPTIN HEMISULFATE MONOHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
LEUPEPTIN HEMISULFATE MONOHYDRATE Suppliers
Global(34)Suppliers
  • Supplier：
    Nanjing TGpeptide
  • Tel：+86-13347807150<br/>+86-13347807150
  • Email：support@tgpeptide.com
  • Country：China
  • ProdList：3279
  • Advantage：58
  • Supplier： VDM Biochemicals
  • Tel：0330-2528181
  • Email：sales@vdmbio.com
  • Country：United States
  • ProdList：510
  • Advantage：64
LEUPEPTIN HEMISULFATE MONOHYDRATE Spectrum
55123-66-5, LEUPEPTIN HEMISULFATE MONOHYDRATERelated Search:
  • Antibiotics
  • 2C20H38N6O42H2OH2O4SS
  • 亮抑酶肽半硫酸盐单水合物
  • 亮肽
  • AC-LEU-LEU-ARG-CHO.H2O4S.AC-LEU-LEU-ARG-CHO
  • 55123-66-5
  • Leupeptin hemisulphate salt monohydrate (Synthetic)
  • Leupeptin (0.5 mg vial)
  • L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-
  • β-Gentiobiose,β-form
  • Ac-Leu-Leu-Arg-aldehyde · sulfate salt
  • (2S)-2-[[(2S)-2-acetamido-4-methyl-pentanoyl]amino]-N-[(2S)-5-[bis(azanyl)methylideneamino]-1-oxo-pentan-2-yl]-4-methyl-pentanamide
  • 6-O-?D-Glucopyranosyl-D-glucopyranose
  • AC-LEU-LEU-ARGINAL 1/2H2SO4 H2O
  • ACETYL-L-LEUCYL-L-LEUCYL-L-ARGININAL HEMISULFATE MONOHYDRATE
  • (2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide
  • (2S)-2-[[(2S)-2-acetamido-4-methyl-pentanoyl]amino]-N-[(1S)-1-formyl-4-guanidino-butyl]-4-methyl-valeramide
  • (S)-2-[(N-Acetyl-L-Leu-L-Leu-)amino]-5-guanidinopentanal
  • (2S)-5-Guanidino-2-[[N-(N-acetyl-L-leucyl)-L-leucyl]amino]pentanal
  • (2S)-2-[(Ac-Leu-Leu-)Amino]-5-guanidinopentanal
  • Gentibiose
  • Ac-Leu-Leu-Arg-aldehyde . sulfate
  • 6-O-B-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE
  • LEUPEPTIN HEMISULFATE MONOHYDRATE
  • methyl-(s)-
  • l-valeramide
  • (s)-2-(2-acetamido-4-methylvaleramido)-n-(1-formyl-4-guanidinobutyl)-4-methy

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