ChemicalBook > CAS DataBase List > HEMATOPORPHYRIN

HEMATOPORPHYRIN

HEMATOPORPHYRIN Structure
HEMATOPORPHYRIN
  • CAS No.14459-29-1
  • Chemical Name:HEMATOPORPHYRIN
  • CBNumber:CB9134564
  • Molecular Formula:C34H38N4O6
  • Formula Weight:598.69
  • MOL File:14459-29-1.mol
HEMATOPORPHYRIN Property
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
  • RTECS  :TS5500000
  • F  :8-10-21
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

HEMATOPORPHYRIN Chemical Properties,Usage,Production

  • Uses antidepressant, antineoplastic
  • Uses Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.
  • Definition ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.
  • Hazard Toxic. Reported to be preferentially absorbed by cancerous tissues, making them fluoresce under UV light.
  • in vivo

    Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels[3].

    Animal Model:Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130[3]
    Dosage:5, 10 mg/kg
    Administration:I.p. daily during the initial 10 days and biweekly for the next 2 months
    Result:No tumor could be palpated a few days after exposure of the rats to light.
    The skin healed completely and regrowth of the hair occurred.
    Massive coagulation necrosis of the tumor 24 h after phototreatment (×40).
  • IC 50 Human Endogenous Metabolite
  • Purification Methods Purify it by dissolving it in EtOH Hematoporphyrin and adding H2O or Et2O to give deep red crystals. It has also been recrystallised from MeOH. UV has max at 615.5, 565, 534.4 and 499.5nm in 0.1N NaOH, and 597, 619, 634, 653, 683 and 701nm in 2N HCl [Falk Porphyrins and Metalloporphyrins Elsevier, NY, p 175 1964, LCCCNo 63-19821.] It is used in the affinity chromatographic purification of Heme proteins [Olsen Methods Enzymol 123 324 1986]. The O-methyl-dimethyl ester has m 203-206o (from CHCl3/MeOH), and the O,O'-dimethyl-dimethyl ester has m 145o (from CHCl3/MeOH). [Paul Acta Chem Scand 5 389 1951, Beilstein 26 III/IV 3157, and 3158 for the HCl.]
HEMATOPORPHYRIN Preparation Products And Raw materials
Raw materials
Preparation Products
HEMATOPORPHYRIN Suppliers
Global(99)Suppliers
  • Supplier：
    airuikechemical co., ltd.
  • Tel：+86-18353166132<br/>+86-18353166132
  • Email：sales02@airuikechemical.com
  • Country：China
  • ProdList：983
  • Advantage：58
  • Supplier：
    Xiamen AmoyChem Co., Ltd
  • Tel：+86-86-5926051114<br/>+8615060885618
  • Email：sales@amoychem.com
  • Country：China
  • ProdList：6383
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    SIMAGCHEM CORP
  • Tel： +86-13806087780
  • Email：sale@simagchem.com
  • Country：China
  • ProdList：17365
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Win-Win chemical CO., Limited
  • Tel：+86-0086-577-64498589<br/>+86-15355981851
  • Email：sales@win-winchemical.com
  • Country：China
  • ProdList：14442
  • Advantage：58
  • Supplier：
    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
  • Country：China
  • ProdList：15395
  • Advantage：58
HEMATOPORPHYRIN Spectrum
14459-29-1, HEMATOPORPHYRINRelated Search:
  • 抑制剂
  • 试剂盒-Elisa试剂盒
  • 生物化学品
  • 生化试剂
  • 核糖、核苷酸及其他类
  • 光敏剂
  • 医药中间体
  • Plasma &amp; Blood Proteins
  • Plasma, Blood, and Related Proteins and Reagents
  • Proteins and Derivatives
  • Natural Dyes
  • Biochemicals and Reagents
  • BioChemical
  • C34H38N4O6
  • 14459-21-1
  • 鸡结合珠蛋白(HP)ELISA试剂盒
  • 血卟啉
  • HEMATOPORPHYRIN (TECHNICAL GRADE, ~30%)
  • 化合物 T19354
  • 8,13-双(1-羟乙基)-3,7,12,17-四甲基-21H,23H-卟吩-2,18-二丙酸
  • 14459-29-1
  • Hematoporphyrin Base
  • HEMATOPORPHYRIN USP/EP/BP
  • Hematoprophyrin USP/EP/BP
  • Recombinant Human Haptoglobin/HP/HP Protein, His Tag
  • Recombinant Human Haptoglobin/HP Protein, His Tag
  • Hematoporphyrin (Technical Grade, ~30%)
  • A-259H10.2
  • 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-
  • HematoporphyrineBase
  • hematoporphyrin free base
  • HEMATOPORPHYRIN IX BASE
  • HEMATOPORPHYRINE
  • HEMATOPORPHYRIN
  • HAEMATOPORPHYRIN
  • 8,13-BIS(1-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID
  • hp
  • HeMatoporphyrin >=45%
  • 1,3,5,8-Tetramethyl-2,4-bis(α-hydroxyethyl)porphine-6,7-dipropionic acid
  • 3-[18-(2-carboxyethyl)-7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid
  • 3-[18-(2-carboxyethyl)-7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphin-2-yl]propionic acid
  • Photodyn
  • NSC-59265
  • 7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphyrin-2,18-dipropionic acid
  • 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-Porphine-2,18-dipropanoic acid
  • ANTI-HPR antibody produced in mouse
  • hematoporphyrinix
  • 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-18-porphinedipropionicacid
  • 21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-te
  • 1,3,5,8-tetramethyl-2,4-bis(alpha-hydroxyethyl)prophine-6,7-dipropionicacid

Home

My