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territrem B

territrem B Structure
territrem B
  • CAS No.70407-20-4
  • Chemical Name:territrem B
  • CBNumber:CB91314602
  • Molecular Formula:C29H34O9
  • Formula Weight:526.57
  • MOL File:70407-20-4.mol
territrem B Property
  • Melting point 200～203℃
  • Boiling point 693.0±55.0 °C(Predicted)
  • Density 1.35±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO: soluble
  • form A solid
  • pka 12.11±0.70(Predicted)
  • color White to off-white
  • FDA UNII 5V1C8SB2ZP
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301+H311-H330
  • Precautionary statements P260-P264-P270-P271-P280-P284-P301+P310-P330-P302+P352-P304+P340-P312-P320-P361+P364-P403+P233-P405-P501

territrem B Chemical Properties,Usage,Production

  • Description Territrem B (TRB) is a fungal metabolite isolated from Aspergillus terreus shown previously to be a potent and irreversible inhibitor of acetylcholinesterase (AChE).
  • Description Territrem B is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 19 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg, and has an LD50 value of 9.06 mg/kg.
  • Uses Territrem B is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem B is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and the organophospates.
  • Uses Territrem B is a potent and irreversible inhibitor of acetylcholinesterase.
  • Biological Activity Territrem B is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 19 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg, and has an LD50 value of 9.06 mg/kg.
  • IC 50 AChE
  • References Territrems, tremorgenic mycotoxins of Aspergillus terreus. Ling K.L. et al., Appl. Env. Microbiol. 1979, 37, 355.
    Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea. Dowd P.F. et al., Entomol. Exp. Appl. 1992, 65, 57.
    Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. Jen-Wei Chen J-W. et al., J. Biol. Chem. 1999, 274, 34916.
territrem B Preparation Products And Raw materials
Raw materials
Preparation Products
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territrem B Spectrum
70407-20-4, territrem BRelated Search:
  • 抑制剂
  • TERRITREM B,ACHE抑制剂
  • 土雷姆B
  • 化合物 TERRITREM B
  • 土震素 B
  • 70407-20-4
  • Territrem B, AChE inhibitor
  • 4H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-9-(3,4,5-trimethoxyphenyl)-, (4aR,6aR,12aS,12bS)-
  • PubChem ID: 114734
  • TERRITREM B(RG)
  • (4aR)-4a,6,6a,12,12a,12b-Hexahydro-4aβ,12aβ-dihydroxy-4,4,6aα,12bα-tetramethyl-9-(3,4,5-trimethoxyphenyl)-4H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione
  • territrem B

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