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8-Hydroxyquinoline-N-oxide

CAS No.1127-45-3
Chemical Name:8-Hydroxyquinoline-N-oxide
CBNumber:CB9112579
Molecular Formula:C9H7NO2
Formula Weight:161.16
MOL File:1127-45-3.mol

8-Hydroxyquinoline-N-oxide Property

Melting point 135-138 °C (lit.)
Boiling point 267 °C(lit.)
Density 1.2480 (rough estimate)
refractive index 1.5050 (estimate)
Flash point 139 °C
storage temp. Inert atmosphere,2-8°C
solubility Soluble in Acetone, Chloroform, Dichloromethane, Ethyl Acetate and Methanol
form Solid
pka 6.03±0.30(Predicted)
color Yellow
BRN 128737
CAS DataBase Reference 1127-45-3(CAS DataBase Reference)
FDA UNII TMI4LD989P
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :N,Xi
Risk Statements :50/53-36/37/38
Safety Statements :60-61-24/25-22-36/37/39-27-26
RIDADR :UN 3077 9/PG 3
WGK Germany :3
RTECS :VC8238500
F :3-10
HS Code :29334900

NFPA 704:

	0
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H317-H351b-H372
Precautionary statements P201-P202-P260-P264b-P270-P272-P280g-P302+P352-P308+P313-P363-P403-P501c

8-Hydroxyquinoline-N-oxide Price More Price(6)

Brand: Sigma-Aldrich
Product number: 122335
Product name : 8-Quinolinol N-oxide
Purity: 98%
Packaging: 5G
Price: ₹9740
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 122335
Product name : 8-Quinolinol N-oxide
Purity: 98%
Packaging: 5G
Price: ₹9740
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich
Product number: 122335
Product name : 8-Quinolinol N-oxide
Purity: 98%
Packaging: 10G
Price: ₹19970
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 122335
Product name : 8-Quinolinol N-oxide
Purity: 98%
Packaging: 10G
Price: ₹19970
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: H1272
Product name : 8-Hydroxyquinoline N-Oxide
Purity:
Packaging: 5G
Price: ₹6900
Updated: 2022/05/26
Buy: Buy

8-Hydroxyquinoline-N-oxide Chemical Properties,Usage,Production

Description A quinoline derivative that displays mutagenic activity. It suppresses luminescence of an indicator bacterium that is named Photobacterium phosphoreum. This chemical forms two kinds of complexes with palladium (II) and Gold (III). One kind is an ion-associated compound containing hydrogen bond and hte other is the six membered metal chelates containing metal-oxygen bonds.
Chemical Properties Yellow Crystalline Solid
Uses A quinoline derivative; shows mutagenic activity.
Definition ChEBI: 8-hydroxyquinoline N-oxide is a quinoline N-oxide carrying a hydroxy substituent at position 8. It is a monohydroxyquinoline and a quinoline N-oxide. It is functionally related to a quinolin-8-ol. It is a conjugate acid of an 8-hydroxyquinoline N-oxide(1-).
General Description 8-Quinolinol N-oxide is a toxicant which can suppress luminescence of an indicator bacterium Photobacterium phosphoreum. It forms two types of complexes with gold(III) and palladium(II): type I are ion-associated compounds containing hydrogen bond and the other is the six-membered metal chelates containing metal-oxygen bonds.
Synthesis 8-hydroxyquinoline-N-oxide was synthesized from 8-hydroxyquinoline. A stirred solution of 8-hydroxyquinoline (25.00 g, 172.2 mmol) in 550 ml of CHCl₃ was cooled to 0° C., and 3 -chloroperoxybenzoic acid (40.00 g, 80% Tech. grade *0.231 mmol=0.185 mmol) was added slowly over 3 minutes. The solution was kept at 0° C. and stirred for 3 hours. During this period, the 3-chlorobenzoic acid byproduct precipitated. The 3-chlorobenzoic acid was removed by filtration and the orange filtrate was concentrated to dryness and the remaining solid was triturated with 2% NH40 H (2*200 ml). The solid was isolated on a frit and washed with H₂O.