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PMPA(NAALADaseinhibitor)

CAS No.173039-10-6
Chemical Name:PMPA(NAALADaseinhibitor)
CBNumber:CB91075110
Molecular Formula:C6H11O7P
Formula Weight:226.12
MOL File:173039-10-6.mol

PMPA(NAALADaseinhibitor) Property

Boiling point 538.8±60.0 °C(Predicted)
Density 1.658±0.06 g/cm3(Predicted)
storage temp. room temp
solubility Soluble to 100 mM in sterile
pka 2.06±0.10(Predicted)
form powder
color white to beige
Water Solubility Soluble to 100 mM in water
FDA UNII XH88WJG9LJ
UNSPSC Code 12352200
NACRES NA.77

Safety

RTECS :SA0454800

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319
Precautionary statements P305+P351+P338

PMPA(NAALADaseinhibitor) Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: SML1612
Product name : 2-PMPA
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: ₹12308.03
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: SML1612
Product name : 2-PMPA
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: ₹49578.5
Updated: 2022/06/14
Buy: Buy

PMPA(NAALADaseinhibitor) Chemical Properties,Usage,Production

Uses 2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia.
Biological Activity Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).
Biochem/physiol Actions 2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII).
in vivo
Intraperitoneal administration of 100 mg/kg 2-PMPA results in maximum concentration in plasma of 275 μg/mL at 0.25 h. The half-life, area under the curve, apparent clearance, and volume of distribution are 0.64 h, 210 μg×h/mL, 7.93 mL/min/kg, and 0.44 L/kg, respectively^[1]. 2-PMPA at 250 mg/kg, in an anesthetized mouse, after an initial rise, produces a rapid decline and a striking attenuation in BOLD signals in gray matter. The signature of 2-PMPA on brain T₂* signals in gray matter at both 167 and 250 mg/kg includes a significant initial rise lasting several minutes^[3]. 2-PMPA has neuroprotective activity in an animal model of stroke and anti-allodynic activity in CCI model. Administration of 2-PMPA (50mg/kg) produces a mean peak concentration of 2-PMPA of 29.66±8.1 μM. This concentration is about 100,000 fold more than is needed for inhibition of NAAG peptidase, and indicates very good penetration to the brain. Administration of 50 mg/kg 2-PMPA (i.p.) produces a continuously increasing extracellular NAAG concentration, which startes directly after application^[4].
storage Desiccate at RT