ChemicalBook > CAS DataBase List > 4-Methylumbelliferyl-beta-D-glucopyranoside

4-Methylumbelliferyl-beta-D-glucopyranoside

CAS No.18997-57-4
Chemical Name:4-Methylumbelliferyl-beta-D-glucopyranoside
CBNumber:CB8853266
Molecular Formula:C16H18O8
Formula Weight:338.31
MOL File:18997-57-4.mol

4-Methylumbelliferyl-beta-D-glucopyranoside Property

Melting point 258-263 °C (dec.)
Boiling point 394.46°C (rough estimate)
Density 1.522
refractive index 1.4430 (estimate)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMF: 5 mg/ml; DMSO: 50 mg/ml
pka 12.73±0.70(Predicted)
form Powder
color White to off-white
Water Solubility Soluble in DMF or water
λmax 320nm(Buffer)(lit.)
BRN 94672
CAS DataBase Reference 18997-57-4(CAS DataBase Reference)
UNSPSC Code 12352204
NACRES NA.32

Safety

Hazard Codes :T+
Risk Statements :26/27/28
Safety Statements :22-24/25
WGK Germany :3
F :3-10-21
HS Code :29389090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

4-Methylumbelliferyl-beta-D-glucopyranoside Price More Price(9)

Brand: Sigma-Aldrich(India)
Product number: M3633
Product name : 4-Methylumbelliferyl β-D-glucopyranoside
Purity: β-glucosidase substrate
Packaging: 100MG
Price: ₹7350.18
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: M3633
Product name : 4-Methylumbelliferyl β-D-glucopyranoside
Purity: β-glucosidase substrate
Packaging: 250MG
Price: ₹14483.85
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M3633
Product name : 4-Methylumbelliferyl β-D-glucopyranoside
Purity: β-glucosidase substrate
Packaging: 500MG
Price: ₹25243.9
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M3633
Product name : 4-Methylumbelliferyl β-D-glucopyranoside
Purity: β-glucosidase substrate
Packaging: 1G
Price: ₹43061.85
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M3633
Product name : 4-Methylumbelliferyl β-D-glucopyranoside
Purity: β-glucosidase substrate
Packaging: 5G
Price: ₹133039.25
Updated: 2022/06/14
Buy: Buy

4-Methylumbelliferyl-beta-D-glucopyranoside Chemical Properties,Usage,Production

Description 4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease. Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.
Chemical Properties White Powder
Uses 4-Methylumbelliferyl β-D-glucopyranoside has been used as substrate:
- in glucosylceramidase β enzyme activity assay in lysosome-enriched fractions from primary hippocampal neurons
- in β-glucosidase assay during yeast fermentation
- to assay glucocerebrosidase 1 (GBA1)-related glucosidase activity in macrophage cell line (RAW)
Uses A fluorogenic substrate in the assay of ?-glucosidase.Fluorescence: max. Abs. 316nm; max. Em. 372nm; e x 10-3: 15
Uses A fluorogenic substrate in the assay of ?-glucosidase. Fluorescence: max. Abs. 316nm; max. Em. 372nm; e x 10-3: 15
Definition ChEBI: A beta-D-glucoside having a 4-methylumbelliferyl substituent at the anomeric position.
Biochem/physiol Actions 4-Methylumbelliferyl β-D-glucopyranoside is a synthetic enzymatic substrate for glycosidase. It has been used as substrate for the β- glucosidase from enterococci.
Purification Methods 4-Methylumbellifer-7-yl--Dglucopyranoside crystallises as the half hydrate from hot H2O. [Constantzas & Kocourek Collect Czech Chem Commun 24 1099 1959, De Re et al. Ann Chim (Rome) 4 9 2089 1959, Courtin-Duchateau & Veyrière Carbohydr Research 65 23, 29 1978, Beilstein 18 III/IV 5152, 8 IV 433, 18/7 V 616.]