9(R)-HETE

Uses

9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. At a concentration of 300 nM, 9(R)-HETE activates RXRγ-dependent transcription 1.5 fold relative to a control.1 Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.

Definition

ChEBI: 9R-HETE is a polyunsaturated fatty acid and a hydroxy fatty acid.

References

[1] Eager, et al. Structural and functional evidence for activation of a chick retinoid X receptor by eicosanoids. Proc. Biol. Sci. 250(1327), 63-69 (1992).