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(-)PPP

(-)PPP Structure
(-)PPP
  • CAS No.477-47-4
  • Chemical Name:(-)PPP
  • CBNumber:CB8708520
  • Molecular Formula:C22H22O8
  • Formula Weight:414.41
  • MOL File:477-47-4.mol
(-)PPP Property
  • Melting point 225-227℃
  • alpha D20 +9.4° (c = 0.7 in chloroform)
  • Boiling point 453.31°C (rough estimate)
  • Density 1.370
  • refractive index 1.4480 (estimate)
  • storage temp. Sealed in dry,2-8°C
  • solubility H2O: soluble
  • form powder
  • pka 13.26±0.40(Predicted)
  • color white
  • Water Solubility H2O: soluble
  • λmax 208 nm (in deoxygenated water)(lit.)
  • Sensitive Light Sensitive
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
  • FDA UNII 0F35AOI227
  • NCI Drug Dictionary picropodophyllin
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :Xi,T
  • Risk Statements  :36/37/38-68-25-21
  • Safety Statements  :26-36-45-36/37
  • RIDADR  :UN 3462 6.1/PG 2
  • WGK Germany  :3
  • RTECS  :LV2510000
  • HazardClass  :6.1
  • Toxicity :LD50 intraperitoneal in mouse: 280mg/kg
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301-H312-H315-H319-H335
  • Precautionary statements P261-P264-P280-P301+P310-P302+P352+P312-P305+P351+P338
(-)PPP Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: T9576
  • Product name : Picropodophyllotoxin
  • Purity: ≥96% (HPLC), powder
  • Packaging: 1MG
  • Price: ₹14234.88
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T9576
  • Product name : Picropodophyllotoxin
  • Purity: ≥96% (HPLC), powder
  • Packaging: 5MG
  • Price: ₹57415.8
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 407247
  • Product name : IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem
  • Purity: The IGF-1R Inhibitor, PPP, also referenced under CAS 477-47-4, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily
  • Packaging: 1MG
  • Price: ₹17000
  • Updated: 2022/06/14
  • Buy: Buy

(-)PPP Chemical Properties,Usage,Production

  • Description Picropodophyllotoxin (477-47-4) is a potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP.1?Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM.1?Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 – 15 μM.2 Exhibits antiangiogenic activity.3?Picropodophyllotoxin attenuates intimal hyperplasia after vascular injury.4?Active in vivo.
  • Uses Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor
  • Uses Insulin growth factor 1 receptor inhibitor, antineoplastic
  • Definition ChEBI: An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.
  • General Description Poly(2,5-bis(3-sulfonatopropoxy)-1,4-phenylene, disodium salt-alt-1,4-phenylene) (PPP-OPSO3) is a water soluble conjugating polymer that can be used as a donor molecule. It has a poly(p-phenylene) skeleton with each repeating unit having two phenylene groups. It can be used for a variety of optoelectronic applications.
  • Biological Activity Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC 50 ~ 1 nM), increases the fraction of cells in the G 2 /M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC 50 = 0.05 - 15 μ M), and has anticancer and antineovascularization activity in vivo .
  • Biochem/physiol Actions Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP can induce G2-M cell cycle arrest even in IGF-IR deficient cells. Hence, the role of PPP in IGF-IR-mediated anticancer functions is debatable.
  • storage Store at +4°C
  • References 1) Girnita et al. (2004), Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth; Cancer Res., 64 236 2) Girnita et al. (2006), The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of iveal melanoma cells; Clin. Cancer Res., 12 1383 3) Menu et al. (2007), Targeting the IGF-1R using picropodophyllin in therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival; Int. J. Cancer, 121 1857 4) Razuvaev et al. (2007), The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling; J. Vasc. Surg., 46 108
(-)PPP Preparation Products And Raw materials
Raw materials
Preparation Products
(-)PPP Suppliers
Global(174)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
(-)PPP Spectrum
477-47-4, (-)PPPRelated Search:
  • Picropodophyllin
  • Insulin-like Growth Factor-1 Receptor Inhibitor
  • 木脂素
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  • 标准品，对照品
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  • 鬼臼苦素
  • 苦鬼臼毒素对照品
  • 苦鬼臼毒素标准品
  • IGF-1R抑制剂(AXL1717)
  • IGF-1R 抑制剂
  • 苦鬼臼素
  • 苦鬼臼脂素
  • 477-47-4
  • Picropodophyllin, 10 mM in DMSO
  • Picropodophyllotoxin, IGF-1R inhibitor
  • Bitter Podophyllotoxin
  • (5R,5aS,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
  • (5R,5aS,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-te...
  • Picropodophyllin (Picropodophyllotoxin, AXL-1717 or PPP)
  • (-)PPP USP/EP/BP
  • Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aS,8aR,9R)-
  • Podophyllotoxin 5a-Epimer
  • Picropodophyllin (AXL1717)
  • IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem
  • AXL1717 (Picropodophyllotoxin)
  • Metacavir
  • Picropodophyllotoxin, >=98%
  • (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
  • AXL-1717
  • AXL1717
  • AXL 1717
  • Pictopodophyllotoxin
  • NSC 36407
  • (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)fur[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
  • IGF-1R Inhibitor, PPP
  • (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
  • NSC 36407, Picropodophyllin, PPP, (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3μ,4μ:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
  • POLY(2,5-BIS(3-SULFONATOPROPOXY)-1,4-PHENYLENE, DISODIUM SALT-ALT-1,4-PHENYLENE)
  • (-)PPP
  • PICROPODOPHYLLIN

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