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1-Tetradecanol

Description References

1-Tetradecanol

CAS No.112-72-1
Chemical Name:1-Tetradecanol
CBNumber:CB8689436
Molecular Formula:C14H30O
Formula Weight:214.39
MOL File:112-72-1.mol

1-Tetradecanol Property

Melting point 35-39 °C(lit.)
Boiling point 289 °C(lit.)
Density 0.823 g/mL at 25 °C(lit.)
vapor density 7.4 (vs air)
vapor pressure <1 hPa (20 °C)
refractive index 1.4454
Flash point >230 °F
storage temp. Store below +30°C.
solubility water: soluble0.00013g/L at 23°C
form Low Melting Solid, Crystalline Powder, Crystals, Flakes, Pellets and/or Chunks
pka 15.20±0.10(Predicted)
Specific Gravity 0.823
color White
Odor fatty
Odor Type waxy
Viscosity 6.4 m.pa.s at 60°C
Water Solubility insoluble
Merck 14,6335
BRN 1742652
Dielectric constant 4.4（48℃）
LogP 5.5
Substances Added to Food (formerly EAFUS) MYRISTYL ALCOHOL
FDA 21 CFR 175.105; 175.300; 176.200
CAS DataBase Reference 112-72-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII V42034O9PU
NIST Chemistry Reference 1-Tetradecanol(112-72-1)
EPA Substance Registry System 1-Tetradecanol (112-72-1)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi
Risk Statements :38-36
Safety Statements :24/25-26
RIDADR :UN 3077 9 / PGIII
WGK Germany :-
RTECS :XB8655000
F :9
Autoignition Temperature :489 °F
TSCA :Yes
HS Code :2905 19 00
HazardClass :9
PackingGroup :III
Hazardous Substances Data :112-72-1(Hazardous Substances Data)
Toxicity :LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H319-H410
Precautionary statements P264-P273-P280-P305+P351+P338-P337+P313-P391

1-Tetradecanol Price More Price(12)

Brand: Sigma-Aldrich(India)
Product number: 8.08146
Product name : 1-Tetradecanol
Purity: for synthesis
Packaging: 1KG
Price: ₹4409.99
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: PHR1135
Product name : Myristyl Alcohol
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1G
Price: ₹8270.3
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 87158
Product name : 1-Tetradecanol
Purity: Selectophore?, ≥99.0%
Packaging: 5G
Price: ₹16962.78
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 8.08146
Product name : 1-Tetradecanol
Purity: for synthesis
Packaging: 100G
Price: ₹4480
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 8.08146
Product name : 1-Tetradecanol
Purity: for synthesis
Packaging: 50KG
Price: ₹88140
Updated: 2022/06/14
Buy: Buy

1-Tetradecanol Chemical Properties,Usage,Production

Description 1-Tetradecanol is a kind of straight-chain saturated fatty alcohol. It is often used as an ingredient in cosmetics such as cold creams because of its emollient properties. It can also be used as the intermediate during the manufacturing of some organic compounds like surfactants. Some studies have shown that it can inhibit the endothelial activation and reduce tissue responsiveness to cytokines, having the potential to treat the periodontitis based on studies on rabbits. It is also employed for the fabrication of temperature-regulated drug release system based on phase-change materials.
References Lehmler, Hans-Joachim, and Paul M. Bummer. "Behavior of 10-(perfluorohexyl)-decanol, a partially fluorinated analog of hexadecanol, at the air–water interface." Journal of fluorine chemistry 117.1 (2002): 17-22.
Hasturk, Hatice, et al. "1-Tetradecanol complex reduces progression of porphyromonas gingivalis–induced experimental periodontitis in rabbits." Journal of periodontology 78.5 (2007): 924-932.
Hasturk, H, et al. "1-Tetradecanol complex: therapeutic actions in experimental periodontitis." Journal of Periodontology 80.7(2009): 1103-13.
Choi, Sung-Wook, Yu Zhang, and Younan Xia. "A temperature-sensitive drug release system based on phase-change materials." Angewandte Chemie International Edition 49.43 (2010): 7904-7908.
Chemical Properties Myristyl alcohol occurs as a white crystalline solid with a waxy odor. Also reported as opaque leaflets or crystals from ethanol.
Chemical Properties white low melting solid or flakes
Uses myristyl alcohol is an emollient often used in hand creams, cold creams, and lotions to give them a smooth, velvety feel. Sources indicate it as being mildly comedogenic and potentially irritating.
Uses 1-Tetradecanol is used as an ingredient in cosmetics such as cold creams. It is an active intermediate in the chemical synthesis of sulfated alcohol. It is also employed in the fabrication of temperature-regulated drug release system based on phase-change materials. It plays a vital role in filling the hollow interiors of gold nanocages in the fabrication of new theranostic system, which has unique feature of photoacoustic imaging.
Uses As emollient for cold creams, etc., also for making the sulfated alcohol whose sodium salt is applicable as a "wetter" in textiles.
Preparation 1-Tetradecanol is prepared from the head oil of the Sperm Whale via the acid and the ester.
Definition ChEBI: 1-Tetradecanol is a long-chain fatty alcohol that is tetradecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group It is a long-chain primary fatty alcohol, a fatty alcohol 14:0 and a primary alcohol.
Production Methods Myristyl alcohol is found in spermaceti wax and sperm oil, and may be synthesized by sodium reduction of fatty acid esters or the reduction of fatty acids by lithium aluminum hydride. It can also be formed from acetaldehyde and dimethylamine.
Synthesis Reference(s) The Journal of Organic Chemistry, 35, p. 1210, 1970 DOI: 10.1021/jo00829a089
General Description Colorless thick liquid (heated) with a faint alcohol odor. Solidifies and floats on water.
Air & Water Reactions Insoluble in water.
Reactivity Profile 1-Tetradecanol is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Health Hazard Low toxicity. Overexposure causes some central nervous system depression. Prolonged skin contact causes skin irritation.
Flammability and Explosibility Not classified
Pharmaceutical Applications Myristyl alcohol is used in oral, parenteral, and topical pharmaceutical formulations. It has been evaluated as a penetration enhancer in melatonin transdermal patches in rats.
Myristyl alcohol has also been tested as a bilayer stabilizer in niosome formulations containing ketorolac tromethamine,and zidovudine.Niosomes containing myristyl alcohol showed a considerably slower release rate of ketorolac tromethamine than those containing cholesterol.This was also observed with the zidovudine formulation.
Safety Myristyl alcohol is used in oral parenteral, and topical pharmaceutical formulations. The pure form of myristyl alcohol is mildly toxic by ingestion and may be carcinogenic; experimental tumorigenic data are available.It is also a human skin irritant. In animal studies of the skin permeation enhancement effect of saturated fatty alcohols, myristyl alcohol exhibited a lower effect when compared with decanol, undecanol, or lauryl alcohol but caused greater skin irritation.A study investigating contact sensitization to myristyl alcohol revealed that patch testing of myristyl alcohol 10% petrolatum should not be carried out owing to observed irritant effects; thus the use of a lower concentration of myristyl alcohol for such tests (5% petrolatum) was recommended.Myristyl alcohol has been associated with some reports of contact allergy.(8,9)A moderate-to-severe erythema and moderate edema are seen when 75 mg is applied to human skin intermittently in three doses over 72 hours.
LD₅₀(rabbit, skin): 7.1 g/kg
LD₅₀(rat, oral): 33.0 g/kg
storage The bulk material should be stored in a well-closed container in a cool, dry place.
Purification Methods Crystallise the alcohol from aqueous EtOH. It has also been purified by zone melting. [Beilstein 1 IV 1864.]
Incompatibilities Myristyl alcohol is combustible when exposed to heat or flame. It can react with oxidizing materials. When heated to decomposition, it emits acrid smoke and irritating fumes.
Regulatory Status Included in the FDA Inactive Ingredients Database (oral tablet: sustained-release; and topical formulations: cream, lotion, suspension). Included in nonparenteral (topical cream) formulations licensed in the UK.