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2'-Deoxy-2'-fluorocytidine

2'-Deoxy-2'-fluorocytidine Structure
2'-Deoxy-2'-fluorocytidine
  • CAS No.10212-20-1
  • Chemical Name:2'-Deoxy-2'-fluorocytidine
  • CBNumber:CB8670324
  • Molecular Formula:C9H12FN3O4
  • Formula Weight:245.21
  • MOL File:10212-20-1.mol
2'-Deoxy-2'-fluorocytidine Property
  • Melting point 167 °C
  • Boiling point 500.1±60.0 °C(Predicted)
  • Density 1.82±0.1 g/cm3(Predicted)
  • refractive index 80 ° (C=1, MeOH)
  • storage temp. Keep in dark place,Sealed in dry,2-8°C
  • solubility Soluble in DMSO, Methanol.
  • pka 12.84±0.70(Predicted)
  • form Powder
  • color White to Off-white
  • Water Solubility Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
  • InChI InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1
  • InChIKey NVZFZMCNALTPBY-XVFCMESISA-N
  • SMILES OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O
  • CAS DataBase Reference 10212-20-1(CAS DataBase Reference)
  • FDA UNII LCY080JPY9
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36
  • HS Code  :29389090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a
2'-Deoxy-2'-fluorocytidine Price More Price(1)
  • Brand: TCI Chemicals (India)
  • Product number: D3614
  • Product name : 2'-Deoxy-2'-fluorocytidine
  • Purity: 
  • Packaging: 1G
  • Price: ₹4300
  • Updated: 2022/05/26
  • Buy: Buy

2'-Deoxy-2'-fluorocytidine Chemical Properties,Usage,Production

  • Description 2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus.
  • Chemical Properties White Solid
  • Uses 2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s pread.
  • in vitro 2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.
  • References [1] Stephen R. Welch. “Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.” Antiviral research 147 (2017): Pages 91-99.
2'-Deoxy-2'-fluorocytidine Preparation Products And Raw materials
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2'-Deoxy-2'-fluorocytidine Spectrum
10212-20-1, 2'-Deoxy-2'-fluorocytidineRelated Search:
  • Nucleosides-2'-F Nucleosides
  • Modified（deoxy）nucleoside
  • Nucleosides
  • 10212-20-1
  • Nucleosides, Nucleotides & Related Reagents
  • Nucleosides and their analogs
  • Biochemistry
  • 原料药
  • 化学试剂
  • 氟类
  • 抑制剂
  • 其它原料及中间体
  • 化工原料及中间体
  • 小核酸药物
  • 核苷原料
  • mRNA体外合成核心原料-Nucleosides
  • 2‘-脱氧氟代修饰类
  • 医药原料
  • 生化试剂-植物激素及核酸类
  • 中间体
  • 核苷，核苷酸，寡核苷酸
  • 植物激素及核酸类
  • 阿糖
  • 生化试剂
  • 核酸
  • 嘧啶核苷酸
  • 杂环化合物
  • C9H12FN3O4
  • C9H12N3O4F
  • C9H12FN3O4xH2O
  • 110212-20-1
  • 2'-脱氧-2-氟胞苷/10212-20-1
  • 2'-脱氧-2'-氟胞苷*5
  • 2'-氟-2'-脱氧胞苷(FDC)
  • 2'-氟-2'-脱氧胞苷水合物
  • 2'-氟-2'-脱氧胞苷(2'-F-DC)
  • 2'-脱氧-2'-氟胞嘧啶核苷
  • 4-氨基-1-((2R,3R,4R,5R)-3-氟-4-羟基-5-(羟甲基)四氢呋喃-2-基)嘧啶-2(1H)-酮
  • 2'-氟-2'-脱氧胞苷, >98.0%(T)
  • 2'-脱氧-2'-氟胞苷水合物
  • 2'-氟脱氧胞苷
  • 2'-氟-2'-脱氧胞苷
  • 2\'-脱氧-2\'-氟胞啶
  • 2'-脱氧-2-氟胞苷
  • 2'-脱氧-2'-氟胞苷
  • 2'-氟-2'-脱氧胞苷(2'-F-2'-DC)
  • 10212-20-1
  • 2''-Deoxy-2''-fluorocytidine
  • 2'-Fluoro-d-Cytidine
  • 2'-F-dC
  • 2'-Deoxy-2'-fluorocytidine
  • 2'-F-2'-deoxycytidine
  • 2'-Deoxy-2"-fuorocytidine
  • 2'-Fluoro-2'-Deoxycytidine
  • 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
  • 2'-Fluoro-2'-Deoxycytidine (FdC)
  • Crimean-Congo hemorrhagic fever,2' Deoxy 2' fluorocytidine,Inhibitor,nucleoside analog,inhibit,Influenza Virus,2'Deoxy2'fluorocytidine,Antiviral,CCHFV
  • 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl...

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