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SR-4835

SR-4835 Structure
SR-4835
  • CAS No.2387704-62-1
  • Chemical Name:SR-4835
  • CBNumber:CB85821187
  • Molecular Formula:C21H20Cl2N10O
  • Formula Weight:499.36
  • MOL File:2387704-62-1.mol
SR-4835 Property
  • Boiling point 886.6±75.0 °C(Predicted)
  • Density 1.72±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO:5.0(Max Conc. mg/mL);10.0(Max Conc. mM)
  • pka 9.13±0.30(Predicted)
  • form Solid
  • color Off-white to light brown
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

SR-4835 Chemical Properties,Usage,Production

  • Uses SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death[1].
  • IC 50 CDK12: 99 nM (IC50); CDK12: 98 nM (Kd); CDK13: 4.9 nM (Kd)
  • References [1] Quereda V, et al. Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer. Cancer Cell. 2019 Oct 8. pii: S1535-6108(19)30424-6. DOI:10.1016/j.ccell.2019.09.004
SR-4835 Preparation Products And Raw materials
Raw materials
Preparation Products
SR-4835 Suppliers
Global(67)Suppliers
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    InvivoChem
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    TargetMol Chemicals Inc.
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    LEAPCHEM CO., LTD.
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    Aladdin Scientific
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  • Email：tp@aladdinsci.com
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SR-4835 Spectrum
2387704-62-1, SR-4835Related Search:
  • 化学试剂
  • 抑制剂
  • 药靶配体
  • 库存
  • C21H20Cl2N10O
  • 化合物SR-4835,10 MM DMSO 溶液
  • N-[(5,6-二氯-2-苯并咪唑基)甲基]-9-(1-甲基-4-吡唑基)-2-(4-吗啉基)-9H-嘌呤-6-胺
  • N-((5,6-二氯-1H-苯并[D]咪唑-2-基)甲基)-9-(1-甲基-1H-吡唑-4-基)-2-吗啉基-9H-嘌呤-6 -胺
  • 化合物SR-4835
  • N-[(5,6-二氯-1H-苯并咪唑-2-基)甲基]-9-(1-甲基-1H-吡唑-4-基)-2-(4-吗啉基)-9H-嘌呤-6-胺
  • 2387704-62-1
  • SR-4835, 10 mM in DMSO
  • N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine
  • N-[(5,6-Dichloro-2-benzoimidazolyl)methyl]-9-(1-methyl-4-pyrazolyl)-2-morpholino-9H-purin-6-amine
  • Cyclin dependent kinase,SR-4835,inhibit,CDK,Apoptosis,SR4835,Inhibitor,SR 4835
  • 9H-Purin-6-amine, N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-
  • SR-4853
  • SR-4835

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