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SR-717

SR-717 Structure
SR-717
  • CAS No.2375421-09-1
  • Chemical Name:SR-717
  • CBNumber:CB47247714
  • Molecular Formula:C15H10F2LiN5O3
  • Formula Weight:353.21
  • MOL File:2375421-09-1.mol
SR-717 Property
  • storage temp. Inert atmosphere,Room Temperature
  • solubility Soluble in DMSO (>25 mg/ml)
  • form solid
  • color Off-white
  • Water Solubility Water: < 0.1 mg/mL (insoluble)
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements
  • Precautionary statements

SR-717 Chemical Properties,Usage,Production

  • Description SR-717 (2375421-09-1) is a cell permeable and exceptionally selective STING agonist (IC50 = 7.8 μM).? It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s.
  • Uses SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1].
  • in vivo

    SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Stinggt/gt mice[1].
    SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming[1].

    Animal Model:WT or Stinggt/gt mice[1]
    Dosage:30 mg/kg
    Administration:Intraperitoneally; once-per-day for 1 week
    Result:Maximally inhibited tumor growth.
  • References Chin et al. (2020), Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic; Science 369 993
SR-717 Preparation Products And Raw materials
Raw materials
Preparation Products
SR-717 Suppliers
Global(65)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
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  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
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    InvivoChem
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  • Email：sales@invivochem.cn
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    LEAP CHEM CO., LTD.
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  • Email：market18@leapchem.com
  • Country：China
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：support@targetmol.com
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  • Supplier：
    Aladdin Scientific
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SR-717 Spectrum
2375421-09-1, SR-717Related Search:
  • 药靶配体
  • 抑制剂
  • 化合物SR-717,10 MM DMSO 溶液
  • 2-(6-(1H-咪唑-1-基)哒嗪-3-甲酰胺基)-4,5-二氟苯甲酸锂
  • 化合物SR-717
  • SR-717(锂盐)(COMPONENT
  • 4,5-二氟-2-[[[6-(1H-咪唑-1-基)-3-哒嗪基]羰基]氨基]-苯甲酸锂盐
  • 2375421-09-1
  • 4,5-difluoro-2-[(6-imidazol-1-ylpyridazine-3-carbonyl)amino]benzoate
  • SR-717, 10 mM in DMSO
  • SR171&SR-717 lithium
  • Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate
  • immunity,MPYS,MITA,inhibit,ISG-THP1,Inhibitor,SR 717,mimetic,TMEM173,STING,SR717,cGAMP,THP1,antitumor,ERIS,SR-717,PD-L1,Stimulator of Interferon Genes
  • SR 717 (lithium salt)
  • SR-717 lithium
  • SR171
  • SR-717

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