Biperiden lactate (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1].
Biperiden lactate (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability[2].
| Animal Model: | Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; everyday; 3 weeks |
| Result: | Tumor size reduced by 83%. |
| Animal Model: | Male Wistar rats (200-250 g)[2] |
| Dosage: | 8 mg/kg |
| Administration: | Intraperitoneal injection; every 8 hours; 10 days |
| Result: | Reduced late seizures by about three times with no affecting emotional memory damage |
