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(4E)-TCO-PEG4-DBCO

(4E)-TCO-PEG4-DBCO Structure
(4E)-TCO-PEG4-DBCO
  • CAS No.1801863-88-6
  • Chemical Name:(4E)-TCO-PEG4-DBCO
  • CBNumber:CB84849386
  • Molecular Formula:C38H49N3O8
  • Formula Weight:675.82
  • MOL File:1801863-88-6.mol
(4E)-TCO-PEG4-DBCO Property
  • Boiling point 891.1±65.0 °C(Predicted)
  • Density 1.22±0.1 g/cm3(Predicted)
  • solubility Soluble in Partially Water Soluble, DMSO, DCM, DMF
  • pka 11.95±0.46(Predicted)
  • form Oil
  • color Colorless to light yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

(4E)-TCO-PEG4-DBCO Chemical Properties,Usage,Production

  • Description TCO-PEG4-DBCO is a heterobifunctional click chemistry reagent containing a TCO and a DBCO moiety. TCO group specifically and efficiently reacts with terrahydrazine at fast speed. DBCO is very reactive toward Azide through copper free click chemistry, the PEG spacer increases the aqueous solubility of the reagent.
  • Uses TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
  • IC 50 Cleavable Linker; PEGs
  • References [1] Rahim MK, et al. Enhancing reactivity for bioorthogonal pretargeting by unmasking antibody-conjugated trans-cyclooctenes. Bioconjug Chem. 2015 Feb 18;26(2):352-60. DOI:10.1021/bc500605g
(4E)-TCO-PEG4-DBCO Preparation Products And Raw materials
Raw materials
Preparation Products
(4E)-TCO-PEG4-DBCO Suppliers
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    TargetMol Chemicals Inc.
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    Alfa Chemistry
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(4E)-TCO-PEG4-DBCO Spectrum
1801863-88-6, (4E)-TCO-PEG4-DBCORelated Search:
  • ADC LINKER
  • C38H49N3O8
  • (4E)-TCO-PEG5-DBCO
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  • (4E)-反式环辛烯-四聚乙二醇-二苯并环辛炔
  • (4E)-反式环辛烯-四聚乙二醇-二苯基环辛炔
  • 反式环辛烯-四聚乙二醇-二苯基环辛炔,TCO-PEG4-DBCO
  • 1801863-88-6
  • TCO-PEG4-DBCO
  • (4E)-TCO-PEG4-DBCO

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