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Famoxadone

CAS No.131807-57-3
Chemical Name:Famoxadone
CBNumber:CB8439206
Molecular Formula:C22H18N2O4
Formula Weight:374.39
MOL File:131807-57-3.mol

Famoxadone Property

Melting point 140.3～141.8℃
Boiling point 491.3±55.0 °C(Predicted)
Density 1.327±0.06 g/cm3(Predicted)
vapor pressure 6.4 x 10^-7 Pa (20 °C)
Flash point 2 °C
storage temp. 0-6°C
solubility DMSO: 100 mg/mL (267.10 mM)
form Solid:particulate/powder
Water Solubility 0.243 mg^-1 (pH 5), 0.011 mg l^-1 (pH 7) at 20 °C
pka 0.63±0.40(Predicted)
color White to yellow
LogP 4.65-5.08 at 20℃ and pH4-7
Surface tension 73mN/m at 90μg/L and 20.4℃
EWG's Food Scores 1
FDA UNII V1C07OR6II
EPA Substance Registry System Famoxadone (131807-57-3)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xn,N,F
Risk Statements :48/22-50/53-36-20/21/22-11
Safety Statements :46-60-61-36-26-16-36/37
RIDADR :UN1648 3/PG 2
WGK Germany :2
Hazardous Substances Data :131807-57-3(Hazardous Substances Data)
Toxicity :LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Joshi, Sternberg)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H302-H312-H319-H332
Precautionary statements P210-P280-P305+P351+P338

Famoxadone Price More Price(2)

Brand: Sigma-Aldrich
Product number: 33495
Product name : Famoxadone solution
Purity: 100?μg/mL in acetonitrile, PESTANAL?, analytical standard
Packaging: 2ML
Price: ₹8498.7
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 33495
Product name : Famoxadone solution
Purity: 100?μg/mL in acetonitrile, PESTANAL?, analytical standard
Packaging: 2ML
Price: ₹8498.7
Updated: 2022/06/14
Buy: Buy

Famoxadone Chemical Properties,Usage,Production

Description Famoxadone is an oxazolidinedione fungicide. Although famoxadone is not a strobilurin derivative, it shares the same mechanism of action. Famoxadone provides control of a broad spectrum of fungi but is particularly effective against downy mildew (P. viticola), late and early blights (Phytophthora infestans and Alternaria solani), the Septoria complex, and barley net blotch at rates of 50 to 200 g ai/ha. Target crops include vines, potatoes/tomatoes, cereals, sugar beets, canola, and cucumber. It shows good protectant, translaminar and residual control, with excellent rainfastness and good crop safety. As was seen for trifloxystrobin, it is particularly effective against grape downy mildew when applied in mixture with cymoxanil. The cereal disease spectrum and level of disease control are improved when famoxadone is mixed with triazole fungicides such as flusilazole.
Chemical Properties Brown Solid
Uses Famoxadone provides preventive control of a broad spectrum of fungal pathogens such as Plasmopara viticola (grape downy mildew), Phytophthora infestans (potato/ tomato late blight), Pseudoperonospora cubensis (cucumber downy mildew), Septoria tritici (wheat leaf blotch), S. nodorum (wheat glume blotch) and Alternaria solani (potato/tomato early blight).
Uses Agricultural fungicide.
Uses Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.
Definition ChEBI: 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione is a member of the class of oxazolidinones that is 1,3-oxazolidine-2,4-dione in which the hydrogen attached to the nitrogen is substituted by a phenylamino group and the hydrogens at position 5 are substituted by methyl and 4-phenoxyphenyl groups. It is an aromatic ether, a carbohydrazide and an oxazolidinone.
Agricultural Uses Fungicide: Tanos 50-DF is recommended for use as a preventative fungicide for control of late blight and early blight on potatoes and field tomatoes.
Trade name DPX-JE874®; FAMOXATE®; MEDLEY®; TANOS-50DF®
Pharmacology Famoxadone inhibits activity of ubiquinol : cytochrome c oxidoreductase at the Qo site of complex III, the same target protein as the strobilurins (34,35). However, studies show a difference in the potency of various strobilurins compared with famoxadone in single amino acid mutants of the cytochrome b protein, suggesting that this compound may interact differently with the target protein (38).
Metabolic pathway Famoxadone undergoes extensive degradation and metabolism in aqueous and soil environments, in wheat plants, rats, goats and hens via common pathways. The primary reactions include the hydrolytic opening of the oxazolidinedione ring, aryl hydroxylation, cleavage of the phenoxyphenyl and the oxazolidinedione-aminophenyl linkages and conjugation. More than 25 degradation products have been identified.
Degradation Famoxadone is relatively stable to hydrolytic degradation under dark conditions in pH 5 buffer solution (DT₅₀ 41 days) (Jernberg et al., 1998a). It was hydrolysed rapidly at pH 7 and pH 9 at 25 °C (DT₅₀ values 2 days and <2 hours, respectively). No sigruficant sunlight-induced degradation was observed at pH 7. Hydrolytic degradation was catalysed in acidic conditions (pH 5) under natural sunlight (DT₅₀ 4.6 days in contrast to 41 days at pH 7). Primary hydrolytic degradation reactions include the opening of the oxazolidinedione ring [to yieldα-hydroxy-α-methyl-4-phenoxyphenylacetic acid 2-phenylhydrazide (2) and 1-carboxy-1-(4-phenoxy-phenyl) ethyl-2-phenylhydrazinecarboxylic acid (3)], and the cleavage of the oxazolidine-aminophenyl linkage to yield various products from both the phenoxyphenyl moiety [ 1-(4-phenoxyphenyl)ethanone (4) and α-hydroxy- α-methyl-4-phenoxyphenylacetiac acid (5)] and the aminophenyl moiety [small amounts of phenol (6), catechol (7) and benzene (8) via the proposed 2-phenylhydrazinecarboxylic acid intermediate (9)] (see Scheme 1).
Toxicity evaluation Famoxadone has an acute oral LD₅₀ > 5,000 mg/kg and an acute percutaneous LD₅₀ > 2,000 mg/kg in rats. It is not a skin or eye irritant, is negative in the Ames test, and is nonteratogenic. It shows very little soil degradation, is nonmobile, and has a good ecotoxicological profile.