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ROQUEFORTINE C

ROQUEFORTINE C Structure
ROQUEFORTINE C
  • CAS No.58735-64-1
  • Chemical Name:ROQUEFORTINE C
  • CBNumber:CB8422875
  • Molecular Formula:C22H23N5O2
  • Formula Weight:389.45
  • MOL File:58735-64-1.mol
ROQUEFORTINE C Property
  • Melting point 202-205℃
  • Boiling point 768.3±60.0 °C(Predicted)
  • Density 1.37±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility chloroform: soluble1mg/mL
  • form White to off-white solid.
  • pka 11.10±0.40(Predicted)
  • color White to off-white
  • biological source Penicillium roqueforti
  • Stability Hygroscopic
  • FDA UNII 4VW6U94XFK
  • UNSPSC Code 12161501
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301+H311+H331
  • Precautionary statements P280
ROQUEFORTINE C Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0406
  • Product name : Roquefortine C
  • Purity: ≥98% (HPLC), from Penicillium roqueforti
  • Packaging: 500μG
  • Price: ₹54958.53
  • Updated: 2022/06/14
  • Buy: Buy

ROQUEFORTINE C Chemical Properties,Usage,Production

  • Description Roquefortine C is a mycotoxin that was first isolated from a strain of P. roqueforti, a species of Penicillium commercially used to ripen blue-veined cheeses. It has also been isolated from other members of the Penicillium genus found in contaminated food products where it displays neurotoxic properties. It has been shown to both activate a P-glycoprotein transport system involved in the efflux of xenobiotics and to inhibit cytochrome P450 3A detoxification enzymes. It has also been used as a biomarker for penitrem A intoxication.
  • Description The third alkaloid isolated from a surface culture of Penicillium roqueforti, roquefortine C is present in only small quantities and the amount obtained is insufficient for the full structure to be established.
  • Uses Roquefortine C is a potent tremorgenic mycotoxin originally isolated from Penicillium roqueforti in 1975 in Japan. Parallel research by Scott and colleagues lead to the structure elucidation of roquefortine C as an unusual diketopiperazine formed by coupling a prenylated tryptophan and histidine. Roquefortine C was subsequently found to be produced by a diverse range of fungi, most notably Penicillium species. Roquefortine is an important mycotoxin as low levels can be found in foodstuffs.
  • Uses Roquefortine C has been used as a standard for the quantification of roquefortine C by high-performance liquid chromatography (HPLC). It has also been used as a standard for the quantification of roquefortine C by liquid chromatography-mass spectrometry (LC?MS/MS).
  • Definition ChEBI: Roquefortine C is a pyrroloindole.
  • Biochem/physiol Actions Roquefortine C is a paralytic neurotoxin of a dioxopiperazine structure produced by a diverse range of fungi, most notably Penicillium species. It has been found in blue cheese and in many other food products due to natural occurrence and contamination. Roquefortine C was found to be active on a wide range of organisms. It inhibits the growth of Gram-positive bacteria, and cockerels treated with roquefortine lost their righting reflex and died within 8-12 hours. Mice injected with roquefortine C experienced neurotoxic properties. Roquefortine C was also reported to inhibit cytochrome P450 as well as tubulin polymerization.
  • References Ohmono et al., Agr. Bioi. Chem., 39, 1333 (1975)
ROQUEFORTINE C Preparation Products And Raw materials
Raw materials
Preparation Products
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ROQUEFORTINE C Spectrum
58735-64-1, ROQUEFORTINE CRelated Search:
  • Antibiotic
  • 抑制剂
  • 药靶配体
  • 抗生素
  • 微生物代谢物
  • C22H23N5O2
  • ROQUEFORTINE C,NEUROTOXIN
  • 娄地青霉素C / 异烟棒曲霉素C
  • 罗克福汀C
  • 甲醇中异烟棒曲霉素C
  • 异烟棒曲霉素C / 娄地青霉素C / 罗奎福汀C
  • 异烟棒曲霉素C
  • 58735-64-1
  • Roquefortine C, Neurotoxin
  • Roquefortine C in Methanol
  • Roquefortine C / isofumigaclavine C
  • PYRAZINO1215PYRROLO23BINDOLE143H5AH
  • RORIFONE95%
  • roquefortine from penicillium*roqueforti
  • 10B-(1,1-DIMETHYL-2-PROPENYL)-6,10B,11,11A-TETRAHYDRO-3-(1H-IMIDAZOL-4-YLMETHYLENE)-2H-PYRAZINO(1',2':1,5)PYRROLO(2,3-B)INDOLE-1,4(3H,5AH)-DIONE
  • ISOROQUEFORTINE C
  • ROQUEFORTINE C
  • ROQUEFORTINE
  • ROQUEFORTIN
  • 2h-pyrazino(1’,2’:1,5)pyrrolo(2,3-b)indole-1,4-(3h,5ah)-dione,6,10b,11,11a-tet
  • 1-dimethyl-2-propenyl)-3-(1h-imidazol-4-ylmethylene)-rahydro-10b-(
  • 2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 10b-(1,1-dimethyl-2-propen-1-yl)-6,10b,11,11a-tetrahydro-3-(1H-imidazol-5-ylmethylene)-,(3E,5aS,10bR,11aS)-
  • Nsc292134
  • Aids-031208
  • Aids031208
  • 2H-Pyrazino[1',2':1,5]pyrrolo[2,3-B]indole-1,4(3H,5ah)-dione, 10B-(1,1-dimethyl-2-propenyl)-6,10B,11,11A-tetrahydro-3-(1H-imidazol-4-ylmethylene)-, (3Z)-
  • (5aS)-3-[(E)-(1H-Imidazole-4-yl)methylene]-10bβ-(1,1-dimethyl-2-propenyl)-1,3,4,5aβ,6,10b,11,11aα-octahydro-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
  • (3E,5aS,5aβ)-10bβ-(1,1-Dimethyl-2-propenyl)-3-(1H-imidazol-4-yl)methylene-6,10b,11,11aα-tetrahydro-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione
  • 10b-(1,1-dimethyl-2-propenyl)-6,10b,11,11a-tetrahydro-3-(1H-imidazol-4-ylmethylene)-2H-pyrazino(1,2:1,5)pyrrolo(2,3-b)indole-1,4(3H,5aH)-dione, Isoroquefortine C, Roquefortin, Roquefortine C

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