ChemicalBook > CAS DataBase List > GINKGETIN

GINKGETIN

GINKGETIN Structure
GINKGETIN
  • CAS No.481-46-9
  • Chemical Name:GINKGETIN
  • CBNumber:CB8350301
  • Molecular Formula:C32H22O10
  • Formula Weight:566.51
  • MOL File:481-46-9.mol
GINKGETIN Property
  • Melting point 297 °C(Solv: acetone (67-64-1))
  • Boiling point 863.7±65.0 °C(Predicted)
  • Density 1.506±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO:64.0(Max Conc. mg/mL);112.97(Max Conc. mM)
    DMSO:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.21(Max Conc. mM)
  • pka 6.18±0.40(Predicted)
  • form powder
  • color Light yellow
  • LogP 4.450 (est)
  • FDA UNII HY5EZW8269
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

GINKGETIN Chemical Properties,Usage,Production

  • Uses Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ[1][2][3][4][5].
  • Definition ChEBI: A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxyge ase 2.
  • in vivo

    Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway[4].
    Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice[5].

    Animal Model:Male Sprague-Dawley rats (200-220 g)[4]
    Dosage:25, 50, 100 mg/kg
    Administration:I.p. 2 hours after the onset of ischemia
    Result:Reduced the neurological de?cit score.
    Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα.
    Decreased the expressions of ICAM-1, COX-2, and iNOS.
    Downregulated downstream in?ammatory factor PGE2 and TNF-α expression.
    Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression.
  • References [1] Hu WH, et, al. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 2019 Nov 20;11(12):1828. DOI:10.3390/cancers11121828
    [2] Ye ZN, et, al. Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. Nat Prod Bioprospect. 2015 Mar 29;5(2):91-97. DOI:10.1007/s13659-015-0056-4
    [3] Xiong M, et, al. Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9. Oncol Rep. 2016 Feb;35(2):1034-40. DOI:10.3892/or.2015.4427
    [4] Li Q, et, al. Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Biosci Biotechnol Biochem. 2019 Apr;83(4):675-683. DOI:10.1080/09168451.2018.1553608
    [5] Lou J, et, al. Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget. 2017 Oct 16;8(54):93131-93148. DOI:10.18632/oncotarget.21862
GINKGETIN Preparation Products And Raw materials
Raw materials
Preparation Products
GINKGETIN Suppliers
Global(168)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
GINKGETIN Spectrum
481-46-9, GINKGETINRelated Search:
  • 黄酮类
  • 抑制剂
  • 试剂
  • 通用生化试剂-天然产物
  • 标准品，对照品
  • 标准品 -中药标准品
  • 黄酮
  • 对照品-中药对照品
  • 分析试剂标准品
  • 植物提取物
  • 对照品
  • 标准品
  • 中药对照品
  • 中草药成分
  • 银杏双黄酮,10 MM DMSO 溶液
  • 银杏双黄酮/黄酮类
  • 5,7-二羟基-8-(5-(5-羟基-7-甲氧基-4-氧代-4H-苯并吡喃-2-基)-2-甲氧基苯基)-2-(4-羟基苯基)-4H-苯并吡喃-4-酮
  • 银杏素标准品
  • 银杏素对照品
  • 银杏黄酮苷
  • 银杏素, >98%
  • 白果双黄酮(银杏双黄酮
  • 银杏双黄酮, 来源于银杏叶
  • 银杏双黄酮/白果双黄酮
  • 银杏素
  • 银杏双黄酮,银杏黄素,银杏素
  • 银杏黄酮甙
  • 白果双黄酮,银杏双黄酮,银杏黄素
  • 白果双黄酮(银杏双黄酮,银杏黄素,银杏素)
  • GINKGETIN 银杏双黄酮
  • 481-46-9
  • Ginkgetin, 10 mM in DMSO
  • Ginkgetin-RM
  • ginkgotin
  • 5,7-Dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-2-(4-hydroxyphenyl)-4H-chromen-4-one
  • anti-tumor,Autophagy,biloba,anti-fungal,Ginkgo,signaling,Wnt,neuroprotective,inhibit,Apoptosis,leaves,anti-inflammatory,biflavone,Ginkgetin,Inhibitor
  • 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)chromen-4-one
  • GINKGETIN USP/EP/BP
  • Ginkgetin, 98%, from Ginkgo biloba L.
  • 4H-1-Benzopyran-4-one,5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-
  • Ginkgetin, >98%
  • GINKGETIN
  • GINKGETIN(RG)(PLEASE CALL)
  • 5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • 5,7-Dihydroxy-8-[2-methoxy-5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • 4',5,5'',7-Tetrahydroxy-4''',7''-dimethoxy-8,3'''-biflavone

Home

My