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3,4-Methylenedioxy-beta-nitrostyrene

3,4-Methylenedioxy-beta-nitrostyrene Structure
3,4-Methylenedioxy-beta-nitrostyrene
  • CAS No.1485-00-3
  • Chemical Name:3,4-Methylenedioxy-beta-nitrostyrene
  • CBNumber:CB8314918
  • Molecular Formula:C9H7NO4
  • Formula Weight:193.16
  • MOL File:1485-00-3.mol
3,4-Methylenedioxy-beta-nitrostyrene Property
  • Melting point 159-163 °C
  • Boiling point 329.36°C (rough estimate)
  • Density 1.4058 (rough estimate)
  • refractive index 1.5200 (estimate)
  • storage temp. Sealed in dry,2-8°C
  • solubility Soluble in DMSO (up to 50 mg/ml).
  • form Yellow to brown solid
  • color Yellow
  • Sensitive Light Sensitive
  • BRN 192350
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
  • InChI InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2
  • InChIKey KFLWBZPSJQPRDD-UHFFFAOYSA-N
  • SMILES O1C2=CC=C(C=C[N+]([O-])=O)C=C2OC1
  • CAS DataBase Reference 1485-00-3(CAS DataBase Reference)
  • EWG's Food Scores 1
  • NIST Chemistry Reference 3,4-Methylenedioxy-«beta»-nitrostyrene(1485-00-3)
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
3,4-Methylenedioxy-beta-nitrostyrene Price More Price(2)
  • Brand: Sigma-Aldrich
  • Product number: 574713
  • Product name : Syk Inhibitor III - CAS 1485-00-3 - Calbiochem
  • Purity: The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation application
  • Packaging: 50MG
  • Price: ₹18270
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 574713
  • Product name : Syk Inhibitor III - CAS 1485-00-3 - Calbiochem
  • Purity: The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used f
  • Packaging: 50MG
  • Price: ₹18270
  • Updated: 2022/06/14
  • Buy: Buy

3,4-Methylenedioxy-beta-nitrostyrene Chemical Properties,Usage,Production

  • Description MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable.
  • Chemical Properties yellow powder
  • Uses MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin.
  • Biological Activity Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism.
  • in vivo

    MNS (20 mg/kg, i.p.) ameliorates experimental burn wound progression in Wistar rats by inhibiting the NLRP3 inflammasome activation[7].
    MNS (30 mg/kg, p.o., 5 days) alleviates DSS-induced mouse colitis by inhibiting the NLRP3 inflammasome[8].
    MNS (20?mg/kg, i.p., 30?min before reperfusion) significantly protects the kidneys from RIR injury in rats by reducing PANoptosis through specific inhibition of NLRP3[9].

  • IC 50 NLRP3 inflammasome
  • References 1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system; J. Biol. Chem., 286 16546
3,4-Methylenedioxy-beta-nitrostyrene Preparation Products And Raw materials
Raw materials
Preparation Products
3,4-Methylenedioxy-beta-nitrostyrene Suppliers
Global(148)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
3,4-Methylenedioxy-beta-nitrostyrene Spectrum
1485-00-3, 3,4-Methylenedioxy-beta-nitrostyreneRelated Search:
  • Inhibitors
  • Ethanes/ethenes
  • 抑制剂
  • 合成有机化合物配体
  • 小分子抑制剂，天然产物
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Spleen Tyrosine Kinase (Syk)
  • Non-Receptor Tyrosine Kinase Inhibitors
  • Kinase/Phosphatase Biology
  • 3,4-亚甲二氧-BETA-硝基苯乙烯,10 MM DMSO 溶液
  • MDBN,不可逆P97抑制剂
  • 3,4-亚甲二氧-BETA-硝基苯乙烯 (阿曲生坦中间体)
  • 3,4-亚甲二氧基-Β-硝基苯乙烯
  • 5-(2-硝基乙烯基)苯并[D][1,3]二氧戊环
  • 4-亚甲二氧-BETA-硝基苯乙烯
  • 3,4-亚甲二氧基-BETA-硝基苯乙烯
  • 3,4-亚甲二氧基-~-硝基苯乙烯
  • 3,4-亚甲基二氧-BETA-硝基苯乙烯
  • 3,4-亚甲二氧-beta-硝基苯乙烯
  • 3,4-亚甲二氧基-B-硝基苯乙烯
  • 3,4-亚甲二氧基-B-硝基苯乙烯,98%
  • 3,4-亚甲基二氧基-Β-硝基苯乙烯
  • 阿曲生坦中间体2
  • 3,4-亚甲二氧-BETA-硝基苯乙烯 500G
  • 1485-00-3
  • MNS, 10 mM in DMSO
  • thrombin,aggregation,NSC170724,Inhibitor,Src,MNS,NSC 170724,activation,inhibit,NSC-170724,Spleen tyrosine kinase,derivative,GPIIb/IIIa,beta-nitrostyrene,Syk,platelet
  • 4-Methylenedioxy-beta-nitrostyrene
  • Syk Inhibitor III - CAS 1485-00-3 - Calbiochem
  • 5-(2-Nitrovinyl)benzodioxole
  • NSC 170724
  • 3,4-Methylenedioxy-β-nitrostyrene
  • MNS (MDBN)
  • MNS (NSC 170724, MDBN)
  • MDBN
  • MNS (3,4-Methylenedioxy-beta-nitrostyrene, MDBN)
  • 5-(2-Nitrovinyl)benzo[d][1,3]dioxole
  • -nitrostyrene, MDBN)
  • MNS (3,4-Methylenedioxy-&beta
  • MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)
  • (E)-5-(2-nitrovinyl)benzo[d][1,3]dioxole
  • 3,4-Methylenedioxy-beta-nitrostyrene,98%
  • Syk Inhibitor III
  • 5-(2-Nitrovinyl)
  • 1,3-Benzodioxole, 5-nitrovinyl-
  • 1,3-Benzodioxole, 5-(2-nitroethenyl)-
  • ,4-Methylenedioxy-1-(2-nitrovinyl)benzene
  • ,4-(Methylenedioxy)-b-nitrostyrene
  • -(2-Nitrovinyl)-3,4-methylenedioxybenzene
  • -(2-Nitrovinyl)-1,3-benzodioxole
  • 5-(2-Nitrovinyl)-1,3-benzodioxole
  • 5-(2-Nitroethenyl)-1,3-benzodioxole
  • 1-(2-Nitrovinyl)-3,4-methylenedioxybenzene
  • 3,4-METHYLENEDIOXY-SS-NITROSTYRENE
  • 3,4-METHYLENDIOXY-BETA-NITROSTYRENE
  • 3,4-methylenedioxy-á-nitrostyrene

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